ZHANG Jian
1. Peking University Shenzhen Hospital, Shenzhen 518036, ChinaWANG Dong
2. Binzhou City Bincheng District Municipal Hospital, Binzhou 256600QI Tiantian
1. Peking University Shenzhen Hospital, Shenzhen 518036, China. 3. National & Local Joint Engineering Research Center of Orthopedic Biomaterials, Shenzhen 518036. 4. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036WU Liangbin
1. Peking University Shenzhen Hospital, Shenzhen 518036, China. 3. National & Local Joint Engineering Research Center of Orthopedic Biomaterials, Shenzhen 518036. 4. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036YANG Qi
1. Peking University Shenzhen Hospital, Shenzhen 518036, ChinaYU Fei
5. Shenzhen Second People’s Hospital, Shenzhen 5180351. Peking University Shenzhen Hospital, Shenzhen 518036, China. 2. Binzhou City Bincheng District Municipal Hospital, Binzhou 256600. 3. National & Local Joint Engineering Research Center of Orthopedic Biomaterials, Shenzhen 518036. 4. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036. 5. Shenzhen Second People’s Hospital, Shenzhen 518035
R-33
Osteoarthritis (OA) is a chronic degenerative disease with a high incidence rate among middle-aged and elderly people. It can cause joint pain, deformity, and functional impairment, leading to a heavy burden on patients and their families. Peroxisome proliferator-activated receptor γ (PPARγ) is a recently discovered ligand-dependent transcriptional regulatory factor that can regulate fat and carbohydrate metabolism, inflammation, and immune processes. Research has shown that the PPARγ gene plays an important role in OA cartilage degeneration, synovitis inflammation, and adipose lesions, and can affect OA progression through signaling pathways such as the AMP-activated protein kinase, Wnt, and sirtuin 1 pathways. This review focuses on the role and mechanism of the PPARγ gene in OA, in relation to jointrelated tissues and key signaling pathways.
