Research progress in the role of vascular smooth muscle cell phenotype switching and cell pyroptosis in abdominal aortic aneurysm

doi:10.3969/j.issn.1671-7856.2024.11.013

Home > Archive>Volume 34, Issue 11, 2024 >100-106. DOI:10.3969/j.issn.1671-7856.2024.11.013

Research progress in the role of vascular smooth muscle cell phenotype switching and cell pyroptosis in abdominal aortic aneurysm
DOI:
                        10.3969/j.issn.1671-7856.2024.11.013
                    
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Author:
                        LIU Xin1,5,6LIU Xin
1. Graduate School of Hebei Medical University, Shijiazhuang 050017, China. 5. Clinical Medicine Research Cener, Hebei General Hospital, Shijiazhuang 050051. 6. Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang 050051
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TANG Hongyue2TANG Hongyue
2. Blood Transfusion Department, Hebei General Hospital, Shijiazhuang 050051
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GUO Chang3,5,6GUO Chang
3. Graduate School, North China University of Science and Technology, Tangshan 063210. 5. Clinical Medicine Research Cener, Hebei General Hospital, Shijiazhuang 050051. 6. Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang 050051
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MA Dong4MA Dong
4. Department of Biochemistry, School of Basic Medicine, Hebei Medical University, Shijiazhuang 050017
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ZHANG Mingming5,6ZHANG Mingming
5. Clinical Medicine Research Cener, Hebei General Hospital, Shijiazhuang 050051. 6. Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang 050051
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Affiliation:1. Graduate School of Hebei Medical University, Shijiazhuang 050017, China. 2. Blood Transfusion Department, Hebei General Hospital, Shijiazhuang 050051. 3. Graduate School, North China University of Science and Technology, Tangshan 063210. 4. Department of Biochemistry, School of Basic Medicine, Hebei Medical University, Shijiazhuang 050017. 5. Clinical Medicine Research Cener, Hebei General Hospital, Shijiazhuang 050051. 6. Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang 050051
Clc Number:R-33
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Abstract:

Abdominal aortic aneurysm (AAA) is a hidden and fatal disease, but its underlying developmental mechanism remains unclear. Phenotypic switching of vascular smooth muscle cells and pyroptosis have been identified as biological processes closely related to the appearance and progression of AAA, with potentially important roles in the mechanism of AAA and in providing new directions for its diagnosis and treatment. In this review, we discuss phenotypic switching of vascular smooth muscle cells and the regulatory relationship between cell pyroptosis and AAA.

Key words:cell pyroptosis; phenotypic switch; atherosclerotic disease; abdominal aortic aneurysm

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Received:May 07,2024
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Online: January 03,2025
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