Cardiovascular disease presents a serious threat to human life, and oxidative stress has been identified as an important factor affecting the occurrence and development of cardiovascular disease. The construction of reliable animal models of oxidative stress is important for the in-depth study of the pathogenesis of cardiovascular diseases and the development of therapeutic drugs. Zebrafish have often been for research into cardiovascular diseases, due to their advantages of easy reproduction, a short developmental cycle, transparent embryos for easy observation, and a highly homologous cardiovascular genetic background with humans. In this paper, we review the application of the zebrafish oxidative stress model in cardiovascular disease and related research progress, to provide a reference for its further application in cardiovascular disease-related research.