Inflammatory skin diseases ( ISD) are characterized by persistent inflammatory cell infiltration and lingering and intractable skin lesions. At present, corticosteroids are the main drugs used in the treatment of ISD.However, due to the characteristics of recurrent and intractable ISD, long-term use of these hormone drugs may cause serious side effects in patients. In recent years, increasingly more studies are confirming that bee venom has significant anti-inflammatory, anti-apoptosis, anti-fibrosis, antibacterial, and other effects and could effectively treat ISD. In this paper, the main active components and anti-inflammatory mechanisms of bee venom are reviewed. The latest attempts to use bee venom for acne, atopic dermatitis, psoriasis, urticaria, and systemic lupus erythematosus are discussed, providing a reference for basic research and the clinical treatment of ISD.