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Home > Archive>Volume 34, Issue 8, 2024 >115-127. DOI:10.3969/j.issn.1671-7856.2024.08.014
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Animal model analysis of atherosclerosis based on clinical symptoms in traditional Chinese medicine and Western medicine
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1. Basic Research Center of Integrated Chinese and Western Medicine for Prevention and Treatment of Vascular Diseases,Hunan University of Chinese Medicine, Changsha 410208, China. 2. Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208

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R-33

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    Abstract:

    On the basis of the clinical characteristics of atherosclerosis ( AS) in traditional Chinese medicine ( TCM) and Western medicine, this paper analyzes common animal models of AS. The coincidence of clinical characteristics of the models was scored in the hope of providing new ideas and a reference for those studying AS.This paper reviews the varieties, modeling method, modeling principles, and characteristics of common animal models of AS. Moreover, similarities among common animal models, in terms of their clinical diagnostic criteria and symptom characteristics, were assessed. High-fat feeding type, mechanical injury combined with high-fat feeding type, genetic engineering combined with high-fat feeding type, chemical induction combined with high-fat feeding type, and combined Chinese clinical syndrome and Western disease AS models are widely established. Comparative analysis showed that balloon injury combined with high fat feeding type, ApoE receptor-knockout mouse combined with high-fat diet type, and phlegm and blood stasis type models of disease and symptom combinations showed a comparatively high level of clinical agreement between Chinese and Western medicine. Presently, most animal models of AS have a high degree of relevance to Western medicine, and the evaluation criteria used for the models are predominately from a Western medicine perspective. Models that combine disease and syndrome are lacking, hindering the development of wholism concepts and treatment through the differentiation of syndromes used in TCM. Therefore, establishing an animal model with a high degree of accuracy and coincidence between TCM and Western perspectives that combines the disease and its TCM symptoms is a top priority for studying the prevention and treatment of AS.

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History
  • Received:March 23,2024
  • Online: October 15,2024
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