Ferroptosis and its role during experimental acute lung injury

doi:10.3969/j.issn.1671-7856.2024.08.012

Home > Archive>Volume 34, Issue 8, 2024 >99-106. DOI:10.3969/j.issn.1671-7856.2024.08.012

Ferroptosis and its role during experimental acute lung injury
DOI:
                        10.3969/j.issn.1671-7856.2024.08.012
                    
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Author:
                        GUO Huanrong1GUO Huanrong
1. School of Basic Medical Sciences/ Institute of Microcirculation, Hebei North College, Zhangjiakou 075000, China
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WANG Jing1,2WANG Jing
1. School of Basic Medical Sciences/ Institute of Microcirculation, Hebei North College, Zhangjiakou 075000, China.2. School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017
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ZHAO Zigang1,3ZHAO Zigang
1. School of Basic Medical Sciences/ Institute of Microcirculation, Hebei North College, Zhangjiakou 075000, China.3. Hebei Key Laboratory of Acute and Critical Disease Pathogenesis and Intervention, Zhangjiakou 075000
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NIU Chunyu1,3NIU Chunyu
1. School of Basic Medical Sciences/ Institute of Microcirculation, Hebei North College, Zhangjiakou 075000, China.3. Hebei Key Laboratory of Acute and Critical Disease Pathogenesis and Intervention, Zhangjiakou 075000
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Affiliation:1. School of Basic Medical Sciences/ Institute of Microcirculation, Hebei North College, Zhangjiakou 075000, China.2. School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017. 3. Hebei Key Laboratory of Acute and Critical Disease Pathogenesis and Intervention, Zhangjiakou 075000
Clc Number:R-33
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Abstract:

Ferroptosis is a non-apoptotic mode of cell death characterized by iron-dependent lipid-peroxideaccumulation-induced membrane lipid peroxidation and mitochondrial atrophy. It differs from other programmed cell deaths in its morphological and biochemical properties. Ferroptosis is regulated by a variety of metabolic pathways that are involved in the acute lung injury induced by hemorrhagic shock, ischemia-reperfusion, sepsis, and radiation. This article reviews the main regulatory mechanisms of ferroptosis and its role in the pathogenesis of acute lung injury in various animal models with the aim of providing new strategies for the prevention and treatment of acute lung injury.

Key words:ferroptosis; glutathione peroxidase 4; lipid peroxidation; acute lung injury

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Received:May 15,2024
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Online: October 15,2024
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