Graduate students are the main practitioners of animal experiments in universities. However, a lack of professional skills and management standards for education on laboratory animals in medical graduate student courses has led to frequent violations of animal experimental guidelines and poses a significant biosafety risks. To ensure the quality of animal experiments and improve the research quality and skills of graduate students, with reference to current practices, this article proposes an innovative teaching model combining a Laboratory Animal Science course with training for medical graduate students. We suggest reforms to teaching content according to scientific research needs, recommend improvements in teaching method, and analyze the significance of the teaching-training model. Our review was written to propose new ideas for strengthening graduate students ’ awareness of animal experiment standardization and improve their scientific research literacy, as well as provide a reference for animal experiment standardization for educators of domestic medical students.