Research progress on the mechanism of miR-138-5p in osteoarthritis

doi:10.3969/j.issn.1671-7856.2024.07.016

Home > Archive>Volume 34, Issue 7, 2024 >142-149. DOI:10.3969/j.issn.1671-7856.2024.07.016

Research progress on the mechanism of miR-138-5p in osteoarthritis
DOI:
                        10.3969/j.issn.1671-7856.2024.07.016
                    
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Author:
                        WU Liangbin1,2,3WU Liangbin
1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
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WENG Jian1,2,3WENG Jian
1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
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LI Aikang1,2,3LI Aikang
1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
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QI Tiantian1,2,3QI Tiantian
1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
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ZHANG Geng1,2,3ZHANG Geng
1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
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ZENG Hui2,3,4ZENG Hui
2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036.4. Department of Osteology, Shenzhen Second People’s Hospital, Shenzhen 518000
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YU Fei1,2,3YU Fei
1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
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Affiliation:1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036.4. Department of Osteology, Shenzhen Second People’s Hospital, Shenzhen 518000
Clc Number:R-33
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Abstract:

MiR-138-5p is a microRNA that plays an important regulatory role in the pathogenesis of osteoarthritis.MiR-138-5p regulates various biological processes, including inflammation, cell apoptosis and proliferation, and matrix degradation in osteoarthritis, by modulating signaling pathways including nuclear factor-κB, Wnt / β-catenin, and phosphoinositide 3-kinase / AKT. This review summarizes the research progress regarding the mechanism of miR-138-5p in osteoarthritis.

Key words:miR-138-5p; osteoarthritis; pathogenesis

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Received:November 28,2023
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Online: August 19,2024
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