Research progress on the involvement of macrophages in myocardial ischemia reperfusion injury mediated by NF-κB signaling pathway

doi:10.3969/j.issn.1671-7856.2024.04.017

Home > Archive>Volume 34, Issue 4, 2024 >139-146. DOI:10.3969/j.issn.1671-7856.2024.04.017

Research progress on the involvement of macrophages in myocardial ischemia reperfusion injury mediated by NF-κB signaling pathway
DOI:
                        10.3969/j.issn.1671-7856.2024.04.017
                    
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Author:
                        LI ShilongLI Shilong
the First Affiliated Hospital of Henan University of CM, Heart Center/ National Regional(Traditional Chinese Medicine)Cardiovascular Diagnosis and Treatment Center, Zhengzhou 450000, China
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WANG HeWANG He
the First Affiliated Hospital of Henan University of CM, Heart Center/ National Regional(Traditional Chinese Medicine)Cardiovascular Diagnosis and Treatment Center, Zhengzhou 450000, China
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CAO YingjieCAO Yingjie
the First Affiliated Hospital of Henan University of CM, Heart Center/ National Regional(Traditional Chinese Medicine)Cardiovascular Diagnosis and Treatment Center, Zhengzhou 450000, China
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Affiliation:the First Affiliated Hospital of Henan University of CM, Heart Center/ National Regional(Traditional Chinese Medicine)Cardiovascular Diagnosis and Treatment Center, Zhengzhou 450000, China
Clc Number:R-33
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Abstract:

Myocardial ischemia reperfusion injury ( MIRI) has become one of the most serious complications affecting the clinical outcome of patients with cardiovascular diseases. The immune inflammatory response of macrophages is closely related to the occurrence and development of MIRI. Many studies have shown that the NF-κB signaling pathway can participate in MIRI regulation by influencing the polarization and inflammatory state of macrophages, pyrodeath, infiltration and other functions, and is a potential target for MIRI therapy. Therefore, this article will review the research progress of NF-κB signaling pathway between macrophage function and MIRI regulation.

Key words:myocardial ischemia reperfusion injury; macrophage; NF-κB pathway

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Received:October 24,2023
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Online: June 20,2024
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