Progress in the study of mechanism of acupuncture in regulating ferroptosis after ischemic stroke

doi:10.3969/j.issn.1671-7856.2024.04.016

Home > Archive>Volume 34, Issue 4, 2024 >129-138. DOI:10.3969/j.issn.1671-7856.2024.04.016

Progress in the study of mechanism of acupuncture in regulating ferroptosis after ischemic stroke
DOI:
                        10.3969/j.issn.1671-7856.2024.04.016
                    
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Author:
                        XUE Jing1,2XUE Jing
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300072, China.2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381
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GAO Ying1,2,3GAO Ying
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300072, China.2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381.3. Tianjin Key Laboratory of Acupuncture and Moxibustion, Tianjin 300381
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WANG Shu4,5WANG Shu
4. Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120. 5. Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300381
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Affiliation:1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300072, China.2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381.3. Tianjin Key Laboratory of Acupuncture and Moxibustion, Tianjin 300381. 4. Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120. 5. Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300381
Clc Number:R-33
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Abstract:

Ischemic stroke (IS) presents a complex pathogenesis that poses numerous challenges in its treatment and rehabilitation. Acupuncture, a traditional Chinese medicine treatment, has garnered widespread attention for its effectiveness in treating IS, particularly its regulation of ferroptosis. Ferroptosis is a type of cell death dependent on iron and lipid peroxidation and is closely linked to neurological impairment following IS. This article reviews the primary mechanisms of ferroptosis post-IS, emphasizing the interconnections among iron metabolism, lipid peroxidation, mitochondrial damage, and ferroptosis. It further explores the mechanisms behind the ability of acupuncture to regulate ferroptosis after IS, including its roles in enhancing mitochondrial function, modulating iron metabolism, alleviating oxidative stress, suppressing inflammatory responses, and influencing various ferroptosis signaling pathways. This paper aims to provide a review of the scientific evidence and theoretical support for comprehensive therapeutic strategies for IS

Key words:acupuncture; ischemic stroke; ferroptosis; iron; lipid peroxidation

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Received:December 11,2023
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Online: June 20,2024
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