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Home > Archive>Volume 29, Issue 9, 2019 >26-31. DOI:10.3969/j. issn. 1671 -7856. 2019. 09. 004
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Observation of renal multi-mode molecular function imaging in female rhesus monkeys of different ages
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(1. Department of Nuclear Medicine, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.2. Yunnan Provincial Key Laboratory of Cell Therapy and Translational Medicine, National and Local Joint Engineering Laboratory of Stem Cell and Immune Cell Biomedical Technology, 920th Hospital of Joint Logistics Support Force of PLA, Kunming 650032. 3. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223)

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R-33

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    Abstract:

    Objective To observe various indexes (GFR, ADC, SUV, and CT value) of the kidney of femalerhesus monkey in different age groups, and explore the influence of age on these indexes. Methods Seventeen femalerhesus monkeys of different ages were selected and divided into juvenile, adult, and old groups. BUN, Cre, and UA weredetected in each rhesus monkey. SPECT/ CT, MRI, and PET/ CT were performed and GFR, ADC, SUVmax, SUVmean, andCT values were measured by workstation. A t test was used for comparison of indicators of left and right kidneys, whileANOVA was used for renal indicators among different age groups. Correlations between renal serologic indicators and GFRwere analyzed by Pearson analysis. Results GFRL, GFRR, GFRtotal, and ADC values in old female rhesus monkeys weresignificantly reduced compared with adult and juvenile groups ( all P < 0. 05). However, there were no significantdifferences in GFRL, GFRR, GFRtotal, or ADC values between the left and right kidneys of all age groups (all P > 0. 05).There were no significant differences in SUVmax, SUVmean, or CT values between the right and left kidneys of each agegroup, or among the three age groups (all P > 0. 05). BUN, Cre, and UA were not significantly different among the threeage groups (all P > 0. 05). Correlation analysis results showed that BUN and Cre were moderately correlated with GFRtotal(r=0. 56, -0. 56, all P < 0. 05). However, there was no significant correlation between UA and GFRtotal ( P > 0. 05).Conclusions This study provides a reference for quantitative analysis of rhesus monkey renal function by SPECT/ CTmolecular functional imaging, and provides basic data for scientific experiments involving rhesus monkey kidney as the gold standard for evaluation of renal function.

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History
  • Received:May 05,2019
  • Online: October 10,2019
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