| 陈婷玉,苏凯奇,阮晓迪,房 璐,张钰涵,刘 昊,冯晓东.中药调控缺血性脑卒中后紧密连接的研究进展[J].中国比较医学杂志,2023,33(1):103~112. |
| 中药调控缺血性脑卒中后紧密连接的研究进展 |
| Research progress of Chinese medicine in regulating tight junction after ischemic stroke |
| 投稿时间：2022-04-18 |
| DOI：10. 3969 / j.issn.1671-7856. 2023. 01. 013 |
| 中文关键词: 缺血性脑卒中 中药 紧密连接 血脑屏障 |
| 英文关键词:ischemic stroke traditional Chinese medicine tight junction blood-brain barrier |
| 基金项目: |
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| Author Name | Affiliation | | CHEN Tingyu | Henan University of Chinese Medicine, Zhengzhou 450046, China | | SU Kaiqi | 1. Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Rehabilitation Center the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000 | | RUAN Xiaodi | Henan University of Chinese Medicine, Zhengzhou 450046, China | | FANG Lu | Henan University of Chinese Medicine, Zhengzhou 450046, China | | ZHANG Yuhan | Henan University of Chinese Medicine, Zhengzhou 450046, China | | LIU Hao | Henan University of Chinese Medicine, Zhengzhou 450046, China | | FENG Xiaodong | 1. Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Rehabilitation Center the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000 |
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| 中文摘要: |
| 缺血性脑卒中(ischemic stroke, IS)是脑血管疾病的主要类型,通常导致全球老龄人口残疾或死亡。紧密连接(tight junction, TJ)与缺血性脑卒中密切相关。脑组织缺血后紧密连接的过度破坏与血脑屏障通透性的增大将加剧缺血性脑损伤的病理进展。大量研究表明中药可以有效修复缺血性脑卒中后脑血管内皮细胞的紧密连接,进而减轻血脑屏障的破坏、促进脑损伤恢复。本综述主要通过阐明中药单体及其提取物、中药复方调控紧密连接来改善缺血性脑卒中神经功能损伤的可能机制,以期为临床治疗发现中药治疗缺血性脑卒中的新靶点提供理论思路。 |
| 英文摘要: |
| Ischemic stroke is a common type of cerebrovascular disease and often leads to death or disability in the global aging population. Tight junction integrity is closely related to ischemic stroke. Excessive destruction of tight junctions and increased permeability of the blood-brain barrier after brain tissue ischemia aggravates the pathological progression of ischemic brain injury. A large number of studies have shown that traditional Chinese medicine can effectively repair the tight junctions between cerebral vascular endothelial cells after ischemic stroke, thereby reducing damage to the blood-brain barrier and promoting recovery after brain injury. This review elucidates the possible mechanisms of the active components of traditional Chinese medicine, including monomers and monomers their extracts, and other compounds, in improving the neurological damage of ischemic stroke by regulating tight junctions. Progress in the discovery of clinical uses of traditional Chinese medicine for ischemic stroke are reviewed, including the new target of cerebral apoplexy. |
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