Although available human papillomavirus (HPV) vaccines can effectively prevent HPV infection, thereis still no effective treatment for individuals who are already infected. HPV exhibits species-specific tropism, therebylimiting understanding and research on HPV infection and carcinogenesis, and there are not ideal animal models, inparticular mouse models, for HPV infection. In 2011,mouse papillomavirus type 1(MmuPV1) was isolated, which cannaturally infect mouse strains, and induce different kinds of tumors like HPV, and it is also the only model available forstudying HPV-related diseases. This optimal model is widely used, for the reason that the MmuPV1-infection mouse modelis a key tool for research because of its small size, easy modification, and the availability of abundant commercial reagents,and so on. Therefore, this mouse infection model provides us with a critical platform for extended HPV studies. In thecurrent review, we summarized related studies about MmuPV1, in order to better facilitate new research on the pathogenesis, prevention and treatment of HPV infection.