Aging is an inevitable outcome for all organisms. Researchers are exploring how to delay senescence andreduce the incidences of age-related diseases, prolong life-span and improve the quality of life in old age. Establishing aginganimal models that show aging phenotypes similar to those of humans is an effective way to explore the mechanisms ofhuman aging and research of anti-aging drugs. There are various animal models, such as nematodes, rodents and primates.In recent years, different types of genetically modified mice have emerged. At the same time, researchers have started touse animal models with different life-spans to conduct comparative studies. As aging is a complex biological process withmany influencing factors, only by conducting fully comparative medical research can we better transform the research results of aging and guarantee healthier aging of human beings.