1.昆明医科大学科研实验中心电子显微镜实验室,昆明 650500;2.昆明医科大学法医学院,国家卫生健康委员会毒品依赖和戒治重点实验室,昆明 650500;3.昆明医科大学基础医学院人体解剖学实验室,昆明 650500
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1. Electron Microscopy Laboratory, Research and Experimental Center, Kunming Medical University, Kunming 650500, China. 2. School of Forensic Medicine, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650500. 3. Department of Human Anatomy, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500
甲基苯丙胺(methamphetamine,METN)作为一种被广泛滥用的新型毒品,具有极强的中枢兴奋作用,其中枢兴奋作用途径涉及一系列中枢高级功能,包括与滥用相关的奖赏与动机、学习与记忆、决策与执行等。METH不仅会引发机体神经毒性,长期使用会造成成瘾者认知功能障碍、人格缺失并引发严重的社会暴力行为。外泌体作为细胞间通信的新载体,参与毒品成瘾的发生和发展。外泌体miRNAs不仅是METH成瘾的重要生物标志物,还参与METH神经毒性反应的各个环节,与其相关的药物作用机制研究可以为METH滥用和依赖的临床诊断和治疗提供新思路。
Methamphetamine(METH) is a new type of abused drug with a strong central stimulant effect. Its excitatory pathway involves a series of central higher-level functions, including drug-related rewards and motivation, learning and memory, decision-making, and execution. METH not only causes neurotoxicity, but its long-term use may also cause cognitive dysfunction, loss of personality, and may lead to serious social violence in addicts. Exosomes, as a novel cell-to-cell carrier, are involved in the occurrence and development of drug addiction, and exosome microRNAs are important biomarkers for METH addiction and are also involved in various aspects of METH-induced neurotoxicity. Eoxosmes may thus be useful therapeutic carriers providing a new approach for the diagnosis and treatment of METH abuse.
周 莹,孙 威,杨根梦,董文娟,戴 睿,洪仕君,李利华.外泌体miRNAs在甲基苯丙胺诱导的神经毒性及戒断药物研发中的研究进展[J].中国比较医学杂志,2024,34(12):117~126.
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