小檗碱防治帕金森病的作用机制研究进展
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作者单位:

1.河南中医药大学第一附属医院脑病中心,郑州 450000;2.河南中医药大学第一临床医学院,郑州 450000;3.郑州大学第三附属医院,郑州 450000

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R-33


Research progress on the mechanism of berberine in the prevention and treatment of Parkinson’s disease
Author:
Affiliation:

1. Encephalopathy Center, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. the First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450000. 3. the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000

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    摘要:

    帕金森病(Parkinson’s disease,PD)是一种主要影响中老年人的神经退行性疾病。其主要的临床表现包括静止性震颤、运动迟缓、肌强直以及平衡障碍等特征。小檗碱是一种天然的异喹啉生物碱。在过去的十年里,许多研究报道了小檗碱在一系列疾病的生理病理过程中发挥至关重要的作用,并发现了小檗碱通过不同的途径在PD发生发展中发挥着积极的作用。本文系统性综述了小檗碱防治PD的作用机制及研究现状,为未来小檗碱在PD临床应用及治疗提供一定的参考。

    Abstract:

    Parkinson’s disease(PD) is a neurodegenerative disease that primarily affects middle-aged and older adults. Its main clinical manifestations include resting tremor, bradykinesia, myotonia, and balance disorders. Berberine is a naturally occurring isoquinoline alkaloid. Several studies over the previous decade have reported that berberine plays a crucial role in the pathophysiologic processes of a range of diseases, including playing an active role in the development of PD via different pathways. This paper systematically reviews the mechanism of action of berberine in the prevention and treatment of PD and the current status of research, to provide references for the future clinical application of berberine for the treatment of PD.

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李泓宇,兰 瑞,唐 琛,刘 双,张 勇,沈晓明.小檗碱防治帕金森病的作用机制研究进展[J].中国比较医学杂志,2024,34(12):96~101.

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  • 收稿日期:2024-08-11
  • 在线发布日期: 2025-03-05
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