1.山东中医药大学中医学院,济南 250355;2.山东省中医经典名方协同创新中心,济南 250355
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1. Shandong University of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Jinan 250355, China. 2. Shandong Traditional Chinese Medicine Classic Famous Collaborative Innovation Center, Jinan 250355
失眠作为一种常见的临床疾病,不仅影响患者的生活质量,还可能引发其他健康问题。中医药在治疗失眠方面历经千年的沉淀与传承,拥有独特优势,通过辨证施治调整人体内在平衡达到治疗效果。为了更好地探讨中医药治疗失眠的机制,制备与人类失眠症状相似的动物模型变得尤为重要。本文归纳总结现有的病证结合模型包括肝郁气滞型、心脾两虚型、心肾不交型、阴血亏虚型4大类,对其具体造模方法、评价指标、模型表现进行探讨,推进中医药认识本病的发病机制,为临床疗效评估和新药研发提供技术支持。
Insomnia is a prevalent clinical condition that not only diminishes the patient’s quality of life but also has the potential to give rise to further health complications. Traditional Chinese medicine (TCM) has been used to treat insomnia for thousands of years, with distinct advantages. TCM uses syndrome differentiation and therapy to achieve its therapeutic effects, by regulating the internal balance of the human body. To gain a deeper understanding of how TCM treats insomnia, it is crucial to create animal models that exhibit insomnia symptoms closely resembling those found in humans. This review summarizes the current disease-syndrome combination models, which can be classified into four categories: liver depression and Qi stagnation, heart-spleen deficiency, heart-kidney incompatibility, and Yin and blood deficiency. This paper focuses on specific modelling method ologies, assessment indicators, and model performances, with the aim of enhancing our understanding of the pathophysiology of insomnia in the context of TCM, and providing technical assistance for clinical efficacy evaluation and the creation of novel drugs.
赵中敏,梁书志,高相烨,侯苏寓,罗丹丹,张 艳,王世军.病证结合失眠动物模型的研究进展[J].中国比较医学杂志,2024,34(12):85~95.
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