Ischemic stroke is a neurological disease that damages brain tissue as a result of an insufficient blood supply to the brain, due to blockage or stenosis of the brain vessels. Increasing evidence has indicated that the Wnt/βcatenin signaling pathway plays an important role in the pathophysiological response to the occurrence and development of ischemic stroke. Programmed cell death includes many forms, such as apoptosis, necrotic apoptosis, pyroptosis, autophagy, PANoptosis, and ferroptosis. In this review, we elucidate the characteristics of these different modes of cell death and their cross-talk relationships with each other, and systematically outline the role of Wnt/β-catenin signaling pathways in the intervention of different cell death modes in ischemic stroke, with the aim of providing references for future clinical and basic research studies.