1.成都市第三人民医院普外科肝胆胰病区,西南交通大学附属医院 & 重庆医科大学附属成都第二临床医学院,成都 610031;2.天津医科大学南开临床学院,天津 300100;3.河北北方学院附属第一医院,河北 张家口 075000
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LIU Zehan
1. Section for Hepato Pancreato Biliary Surgery, Department of General Surgery, the Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & the Second Affiliated Hospital of Chengdu,Chongqing Medical University, Chengdu 610031, China. 2. Tianjin Medical University Nankai Hospital,Tianjin 3001001. Section for Hepato Pancreato Biliary Surgery, Department of General Surgery, the Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & the Second Affiliated Hospital of Chengdu,Chongqing Medical University, Chengdu 610031, China. 2. Tianjin Medical University Nankai Hospital,Tianjin 300100. 3. the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000
胆管癌是一种具有胆道上皮特征的恶性肿瘤。 目前胆管癌早期诊断困难、治疗效果欠佳。 其微环境包括丰富的纤维化间质和多种细胞类型,这些成分通过促进迁移、抑制免疫反应、诱导血管和淋巴管生成等机制与肿瘤细胞相互作用,促进胆管癌的发展和转移。 免疫治疗是当前肿瘤治疗的重要手段之一,而胆管癌的免疫治疗也取得了一定的进展。 本文综述了胆管癌免疫微环境的特征、与免疫治疗的关系及前沿的治疗策略。
Cholangiocarcinoma is a malignant tumor with biliary epithelial features. The early diagnosis of cholangiocarcinoma is currently difficult and the treatment outcomes are poor. Its microenvironment includes abundant fibrotic mesenchyme and a variety of cell types, which promote the development and metastasis of cholangiocarcinoma by interacting with tumor cells through mechanisms such as facilitating migration, suppressing the immune response, and inducing angiogenesis and lymphangiogenesis. Immunotherapy is an important tumor treatment approach, and immunotherapy for cholangiocarcinoma has made some progress. This article reviews the characteristics of the immune microenvironment of cholangiocarcinoma, its relationship with immunotherapy, and cutting-edge therapeutic strategies.
刘泽涵,刘双晴,武雪亮,杨 琴,隋晓军.胆管癌免疫微环境特征与免疫治疗:机制、挑战与前景[J].中国比较医学杂志,2024,34(7):168~174.
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