miR-138-5p 在骨关节炎中作用机制的研究进展
作者:
作者单位:

1.北京大学深圳医院骨关节科,广东 深圳 518036;2.骨科生物材料国家地方联合工程研究中心,广东 深圳 518036;3.深圳市骨科疾病与生物材料研究重点实验室,广东 深圳 518036;4.深圳市第二人民医院骨科,广东 深圳 518000

中图分类号:

R-33


Research progress on the mechanism of miR-138-5p in osteoarthritis
Author:
  • WU Liangbin 1,2,3

    WU Liangbin

    1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
    在期刊界中查找
    在百度中查找
    在本站中查找
  • WENG Jian 1,2,3

    WENG Jian

    1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
    在期刊界中查找
    在百度中查找
    在本站中查找
  • LI Aikang 1,2,3

    LI Aikang

    1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
    在期刊界中查找
    在百度中查找
    在本站中查找
  • QI Tiantian 1,2,3

    QI Tiantian

    1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
    在期刊界中查找
    在百度中查找
    在本站中查找
  • ZHANG Geng 1,2,3

    ZHANG Geng

    1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
    在期刊界中查找
    在百度中查找
    在本站中查找
  • ZENG Hui 2,3,4

    ZENG Hui

    2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036.4. Department of Osteology, Shenzhen Second People’s Hospital, Shenzhen 518000
    在期刊界中查找
    在百度中查找
    在本站中查找
  • YU Fei 1,2,3

    YU Fei

    1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036
    在期刊界中查找
    在百度中查找
    在本站中查找
Affiliation:

1. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.2. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036.3. Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036.4. Department of Osteology, Shenzhen Second People’s Hospital, Shenzhen 518000

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • | |
  • 文章评论
    摘要:

    miR-138-5p 作为一种微小 RNA,在骨关节炎发病中起重要调节作用,其可通过 NF-κB、Wnt / βcatenin、PI3K/ AKT 等信号通路作用调节细胞的炎症、细胞凋亡与增殖、基质降解等生物学过程进而影响骨关节炎的发生和发展。 笔者就 miR-138-5p 对骨关节炎作用机制的研究进展作一综述。

    Abstract:

    MiR-138-5p is a microRNA that plays an important regulatory role in the pathogenesis of osteoarthritis.MiR-138-5p regulates various biological processes, including inflammation, cell apoptosis and proliferation, and matrix degradation in osteoarthritis, by modulating signaling pathways including nuclear factor-κB, Wnt / β-catenin, and phosphoinositide 3-kinase / AKT. This review summarizes the research progress regarding the mechanism of miR-138-5p in osteoarthritis.

    参考文献
    相似文献
    引证文献
引用本文

吴凉彬,翁 鉴,李艾康,齐天天,张 耕,曾 晖,于 斐. miR-138-5p 在骨关节炎中作用机制的研究进展[J].中国比较医学杂志,2024,34(7):142~149.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2023-11-28
  • 在线发布日期: 2024-08-19
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭