脂质组学在慢性肺部疾病生物标志物发现中的应用
作者:
作者单位:

1.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州 450046;2.河南省中医药防治呼吸病重点实验室,郑州 450046;3.河南中医药大学中医药科学院,郑州 450046;4.河南中医药大学第一附属医院,郑州 450000

中图分类号:

R-33


Lipidomics driven biomarker discovery in chronic lung disease
Author:
  • ZHANG Ang 1,2

    ZHANG Ang

    1. Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China.2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046
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  • DU Yan 1,2,3

    DU Yan

    1. Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China.2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046
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  • XIE Yang 1,2,4

    XIE Yang

    1. Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China.2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046. 4. the First Affiliated Hospital of Henan University of CM Henan University of Chinese Medicine, Zhengzhou 450000
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  • LIU Xinguang 1,2,3

    LIU Xinguang

    1. Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China.2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046
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Affiliation:

1. Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China.2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046. 4. the First Affiliated Hospital of Henan University of CM Henan University of Chinese Medicine, Zhengzhou 450000

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    摘要:

    慢性肺部疾病(CLD)通常包括慢性阻塞性肺疾病、哮喘、特发性肺纤维化等。 研究表明,CLD 与脂质代谢紊乱密切相关,因此脂质作为 CLD 的生物标志物,对于疾病的诊断、预防及治疗过程中的监控可能有着重要价值。 本文从脂质组学技术方法、脂质组学临床样本选择、CLD 生物标志物发现和 CLD 不同中医证侯区分 4 个方面讨论脂质组学在 CLD 生物标记物研究中的应用。

    Abstract:

    Chronic lung diseases (CLD) include chronic obstructive pulmonary disease, asthma, and idiopathic pulmonary fibrosis. Studies have shown that CLD are closely related to disorders in lipid metabolism. Therefore, lipids, as biomarkers of CLD, may be of great value in the diagnosis, prevention, and monitoring of disease treatment. This review discusses lipidomics from four major aspects: the technical Methods of lipidomics, the selection of clinical samples for lipidomics, the discovery of biomarkers for CLD, and the differentiation of traditional Chinese medicine syndromes from CLD.

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张 昂,杜 燕,谢 洋,刘新光.脂质组学在慢性肺部疾病生物标志物发现中的应用[J].中国比较医学杂志,2024,34(7):131~141.

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历史
  • 收稿日期:2023-07-09
  • 在线发布日期: 2024-08-19
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