SHP-2 在肿瘤相关巨噬细胞中的研究进展
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作者单位:

1.河北北方学院附属第一医院 普通外科,河北 张家口 075000;2.河北北方学院附属第一医院 肿瘤研究所,河北 张家口 075000;3.河北北方学院,河北 张家口 075000;4.天津医科大学附属南开临床学院,天津 300100

中图分类号:

R-33


Research progress on the role of SHP-2 in tumor-associated macrophages
Author:
Affiliation:

1. Department of General Surgery, the First Hospital Affiliated to Hebei North University, Zhangjiakou 075000, China. 2. Cancer Research Institue, the First Hospital Affiliated to Hebei North University, Zhangjiakou 075000. 3. Hebei North University, Zhangjiakou 075000. 4. Nankai Clinical College Affiliated to Tianjin Medical University, Tianjin 300100

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    摘要:

    肿瘤相关巨噬细胞(TAMs)是肿瘤免疫微环境(TIME)中的优势细胞群,是TIME 中免疫系统抑制和肿瘤细胞增殖最重要的调节细胞。Src 同源2 蛋白酪氨酸磷酸酶2(SHP-2)是一种非受体蛋白酪氨酸磷酸酶,该磷酸酶在从细胞表面到细胞核的信号传递中发挥重要作用,且是介导细胞增殖和分化的关键细胞内调节因子,参与多种生长因子和细胞因子的信号通路。最近的研究表明,SHP-2 是决定TAMs 功能的一个关键酶,但是由于其功能多变,在不同的实体瘤微环境中发挥不同甚至是相反的作用。基于此,本文综述了SHP-2 在TAMs 功能及在相关实体瘤中的作用,为肿瘤的免疫和靶向治疗提供坚实的科学依据。

    Abstract:

    Tumor-associated macrophages (TAMs) are the predominant cell group in the tumor microenvironment(TME) and are the most important regulatory cells of immune system suppression and tumor cell proliferation in TIME. Src homology-2 domain-containing protein tyrosine phosphatase 2 (SHP-2) is a non-receptor protein tyrosine phosphatase that plays an important role in the transmission of signals from the cell surface to the nucleus. SHP-2 is a key intracellular regulatory factor mediating cell proliferation and differentiation and is involved in a variety of growth factor and cytokine signaling pathways linking the cell surface to the nucleus. Recent studies have shown that SHP-2 is a key enzyme in determining the function of TAMs, but because of its variable function, it plays different or even opposite roles in different solid TMEs. This paper reviews the function of SHP-2 in TAMs and related solid tumors to provide a comprehensive reference for tumor immunity and targeted therapy research.

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武雪亮,樊建春,郭 飞,张 琦,薛 军,王西墨,孙光源,刘建玲,韩 磊,高树全. SHP-2 在肿瘤相关巨噬细胞中的研究进展[J].中国比较医学杂志,2024,34(1):171~176.

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  • 收稿日期:2023-05-09
  • 在线发布日期: 2024-03-04
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