1.新疆医科大学,乌鲁木齐 830000;2.新疆维吾尔自治区人民医院,乌鲁木齐 830000
R-33
1. Xinjiang Medical University, Urumqi 830000, China. 2. Xinjiang Uygur Autonomous Region People’s Hospital, Urumqi 830000
外泌体是由脂质双分子层包裹的一种细胞外囊泡(EVs),包含蛋白质、脂质、DNA、RNA、miRNA、lncRNA 等多种物质。外泌体参与细菌感染过程中的病原识别、抗原呈递、自噬调节、免疫激活和免疫抑制。研究表明外泌体miRNA、lncRNA 和蛋白质在调节机体抗菌反应中发挥重要作用。本文综述了外泌体对几种胞内菌和胞外菌感染的免疫调节作用,为研究外泌体与细菌感染之间的相互作用提供依据。
Exosomes are small endosomally derived extracellular vesicles with a lipid bilayer structure, and they contain substances, such as proteins, lipids, DNA, RNA, micro(mi)RNA, and long non-coding(lnc)RNA. Exosomes participate in pathogen recognition, antigen presentation, autophagy regulation, immune activation and immunosuppression in bacterial infections. Studies have shown that miRNA, lncRNA, and proteins in exosomes play important roles in regulating antibacterial reactions in organisms. We reviewed the immunomodulatory effects of exosomes on several intracellular and extracellular bacterial infections to provide a reference for those studying the interactions between exosomes and bacterial infections.
李书灵,李智伟.外泌体对细菌感染免疫调节机制的研究进展[J].中国比较医学杂志,2024,34(1):158~164.
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