1.浙江中医药大学第一临床医学院,杭州 310053;2.浙江省中医院心血管内科,杭州 310006
R-33
1. the First Clinical Medical College of Zhejiang Chinese Medicinal University, Hangzhou 310053, China. 2. Department of Cardiology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006
细胞焦亡是一种程序性死亡方式,活化的天冬氨酸酶-1(caspase-1)可以诱导焦亡的发生,促进炎症因子的释放,引发剧烈的炎症反应。根据依赖的caspase 不同,细胞焦亡可分为caspase-1 介导的典型炎症小体途径和人caspase-4/5(或小鼠caspase-11)介导的非典型炎症小体途径。近年来研究发现细胞焦亡与动脉粥样硬化的发生、发展、转归密切相关。本文分别从内皮细胞、血管平滑肌细胞和巨噬细胞三种细胞焦亡在动脉粥样硬化发生发展中的作用和机制作一综述,旨在为动脉粥样硬化发病机制和诊断治疗提供新的研究思路。
Pyroptosis is a programmed mode of cell death. Activated caspase-1 can induce the occurrence of pyroptosis, promote the release of inflammatory factors, and trigger a violent inflammatory response. Depending on the type of caspase involved, pyroptosis can be divided into a caspase-1-mediated typical inflammasome pathway and a human caspase-4/5 (or mouse caspase-11)-mediated atypical inflammasome pathway. In recent years, studies have found that pyroptosis is closely related to the occurrence, development, and prognosis of atherosclerosis. This article reviews the roles and mechanisms of endothelial cells, vascular smooth muscle cells, and macrophage cells in the occurrence and development of atherosclerosis, with the aim of promoting new ideas for research into the pathogenesis, diagnosis, and treatment of atherosclerosis.
黄舒宁,蔡宏文.细胞焦亡与动脉粥样硬化关系进展[J].中国比较医学杂志,2024,34(1):146~150.
复制