1.成都中医药大学针灸推拿学院,成都 610075;2.成都中医药大学研究生院,成都 610075;3.成都中医药大学资产与实验室管理处,成都 611137
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1. School of Acupuncture-Moxibustion, Chengdu University of TCM, Chengdu 610075, China. 2. Graduate School, Chengdu University of TCM, Chengdu 610075. 3. Office of Asset and Laboratory Management, Chengdu University of TCM, Chengdu 611137
糖尿病周围神经病变是糖尿病常见并发症之一,目前对其发病机制的认识不够明确,且缺乏有效治疗手段,需要利用动物实验进行深入研究。造模成功与否的判定标准和周围神经功能恢复的评价方法是开展糖尿病周围神经病变动物实验的关键,但对于2 型糖尿病周围神经病变模型评价方法的整理分析较缺乏。因此笔者查阅近年资料,从小神经纤维和大神经纤维两方面总结分析了2 型糖尿病周围神经病变动物模型评价方法,并提出未来可能的发展方向,以期为相关研究提供参考。
Diabetic peripheral neuropathy is a common diabetic complication. Presently, our understanding of its pathogenesis is incomplete, and there are no effective treatment options. In-depth research requires the use of animal experiments. The criteria for modeling success and the evaluation method for peripheral nerve function recovery are critical for carrying out animal experiments into type 2 diabetic peripheral neuropathy. However, but there has been a lack of systematic interrogation and analysis of the evaluation method used with type 2 diabetic peripheral neuropathy models. Therefore, the author reviewed the recent data, summarized and analyzed the evaluation method used for animal models of type 2 diabetic peripheral neuropathy of small and large nerve fibers, and proposed future directions for development, providing a reference for related research.
朱紫约,王 路,姚俊鹏,刘辉麟,李艳秋,李 瑛,张 微.2 型糖尿病周围神经病变动物模型评价的研究进展[J].中国比较医学杂志,2024,34(1):139~145, 157.
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