外泌体对骨组织细胞的影响及应用的研究进展
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作者单位:

1.甘肃中医药大学中医临床学院,兰州 730030;2.中国人民解放军联勤保障部队第九四〇医院基础医学实验室,兰州 730050;3.甘肃省干细胞与基因药物重点实验室,兰州 730050

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R-33


Research progress on the effect of exosomes on bone histocytes and its application
Author:
Affiliation:

1. Clinical College of Traditional Chinese Medicine, Gansu University, Lanzhou 730030, China. 2. Basic Medical Laboratory, The 940th Hospital of Joint Logistic Support Force of Chinese PLA, Lanzhou 730050. 3. Key Laboratory of Stem Cells and Gene Drug of Gansu Province, Lanzhou 730050

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    摘要:

    近年来外泌体作为细胞间通讯的媒介,为细胞间的信息交换提供了新的视角。来源于不同细胞的外泌体,如间充质干细胞、成骨细胞、破骨细胞及其前体被认为在骨重建过程中发挥关键作用。众多研究表明常见的骨代谢疾病如骨质疏松症、骨折和骨性关节炎等与外泌体有明显的相关性。双磷酸盐类药物干预、自体和同种异体植骨等治疗手段虽能起到不错的疗效,但可能会导致多种并发症以及不良反应,因此开发骨再生能力强、并发症发生率更低、更加精准的靶向新疗法是非常有意义的。本文对不同来源的外泌体对骨组织细胞的影响和相关骨代谢疾病治疗的应用进行综述,为开发新的骨再生治疗方法提供思路。

    Abstract:

    In recent years, exosomes have been used as a medium for cell-cell communication, providing a new perspective for information exchange between cells. Exosomes from various cell types, such as mesenchymal stem cells, osteoblasts, osteoclasts, and their precursors, are play an important role in bone remodeling. Many studies have shown that common bone metabolic diseases, such as osteoporosis, fracture, and osteoarthritis, have obvious correlations with exocrine bodies. Although bisphosphonate drug treatment, autologous and allograft bone grafting, and other treatment method achieve good result , they may lead to various complications and adverse reactions. Therefore, it is very meaningful to develop new targeted therapies with a strong bone regeneration ability, lower complication rate, and more accuracy. Therefore, this article reviews the mechanism of exosomes from various sources acting on bone tissue cells and the application of related bone metabolism disease treatments to provide ideas for developing new bone regeneration treatment method.

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吴 西,王中琪,宋慕格,杨世超,高玉海,陈克明.外泌体对骨组织细胞的影响及应用的研究进展[J].中国比较医学杂志,2023,33(6):108~113.

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  • 收稿日期:2022-10-25
  • 在线发布日期: 2023-08-18
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