FEM1B 的结构与功能及在肿瘤和HIV 感染中的作用
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北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,国家卫生健康委员会人类疾病比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京 100021

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R-33


Structure and function of FEM1B in cancer and HIV infection
Author:
  • YANG Chenbo

    YANG Chenbo

    Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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  • CONG Zhe

    CONG Zhe

    Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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  • XUE Jing

    XUE Jing

    Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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Affiliation:

Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China

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    摘要:

    FEM1B 是一种高度保守的基因,其编码的蛋白FEM1B 是锚定重复蛋白家族的一员,其空间构象中包含7 个串联的模体。FEM1B 能够参与调控包括细胞凋亡、蛋白质泛素化修饰、细胞还原应激和DNA 复制应激等在内的多种生物学功能。研究发现,FEM1B 能够促进结直肠癌、人T 细胞急性淋巴细胞白血病和弥散性大B 细胞淋巴瘤中肿瘤细胞的凋亡,在非小细胞肺癌中,FEM1B 的表达下调能够抑制肿瘤细胞的增殖,侵袭和迁移。此外,FEM1B 的结构与HIV 调控蛋白Vif 具有一定的相关性。FEM1B 的上述特征可能使其成为癌症治疗和调控HIV 感染的一个新靶点。

    Abstract:

    FEM1B is a highly conserved gene, and the protein encoded by FEM1B is a member of the anchorrepeat protein family. Its spatial conformation contains 7 modules in series. FEM1B is involved in the regulation of a variety of biological functions, including apoptosis, protein ubiquitination modification, cell reductive stress and DNA replication stress. FEM1B has been shown to promote apoptosis of tumor cells in colorectal cancer, human T-cell acute lymphoblastic leukemia, and diffuse large B-cell lymphoma, while downregulation of FEM1B inhibits proliferation, invasion, and migration of tumor cells in non-small cell lung cancer. In addition, the structure of FEM1B is related to the HIV regulatory protein Vif. These characteristics of FEM1B may make it a new target for cancer treatment and the regulation of HIV infection.

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杨晨波,丛 喆,薛 婧. FEM1B 的结构与功能及在肿瘤和HIV 感染中的作用[J].中国比较医学杂志,2023,33(5):112~117.

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  • 收稿日期:2022-11-22
  • 在线发布日期: 2023-06-15
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