北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,国家卫生健康委员会人类疾病比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京 100021
R-33
YANG Chenbo
Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, ChinaCONG Zhe
Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, ChinaXUE Jing
Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, ChinaComparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
FEM1B 是一种高度保守的基因,其编码的蛋白FEM1B 是锚定重复蛋白家族的一员,其空间构象中包含7 个串联的模体。FEM1B 能够参与调控包括细胞凋亡、蛋白质泛素化修饰、细胞还原应激和DNA 复制应激等在内的多种生物学功能。研究发现,FEM1B 能够促进结直肠癌、人T 细胞急性淋巴细胞白血病和弥散性大B 细胞淋巴瘤中肿瘤细胞的凋亡,在非小细胞肺癌中,FEM1B 的表达下调能够抑制肿瘤细胞的增殖,侵袭和迁移。此外,FEM1B 的结构与HIV 调控蛋白Vif 具有一定的相关性。FEM1B 的上述特征可能使其成为癌症治疗和调控HIV 感染的一个新靶点。
FEM1B is a highly conserved gene, and the protein encoded by FEM1B is a member of the anchorrepeat protein family. Its spatial conformation contains 7 modules in series. FEM1B is involved in the regulation of a variety of biological functions, including apoptosis, protein ubiquitination modification, cell reductive stress and DNA replication stress. FEM1B has been shown to promote apoptosis of tumor cells in colorectal cancer, human T-cell acute lymphoblastic leukemia, and diffuse large B-cell lymphoma, while downregulation of FEM1B inhibits proliferation, invasion, and migration of tumor cells in non-small cell lung cancer. In addition, the structure of FEM1B is related to the HIV regulatory protein Vif. These characteristics of FEM1B may make it a new target for cancer treatment and the regulation of HIV infection.
杨晨波,丛 喆,薛 婧. FEM1B 的结构与功能及在肿瘤和HIV 感染中的作用[J].中国比较医学杂志,2023,33(5):112~117.
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