线粒体损伤与慢性阻塞性肺疾病骨骼肌功能障碍及中医药治疗进展

doi:10. 3969 / j.issn.1671-7856. 2022. 02. 020

首页 > 过刊浏览>2022年第32卷第2期 >133-137,144. DOI:10. 3969 / j.issn.1671-7856. 2022. 02. 020

线粒体损伤与慢性阻塞性肺疾病骨骼肌功能障碍及中医药治疗进展
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 02. 020
                    
作者:
                        赵高远赵高远
1.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州 450046;2.河南省中医药防治呼吸病重点实验室,郑州 450046
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苗玉芳苗玉芳
1.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州 450046;2.河南省中医药防治呼吸病重点实验室,郑州 450046
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侯润苏侯润苏
1.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州 450046;2.河南省中医药防治呼吸病重点实验室,郑州 450046
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李康沉李康沉
1.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州 450046;2.河南省中医药防治呼吸病重点实验室,郑州 450046
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田燕歌田燕歌
1.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州 450046;2.河南省中医药防治呼吸病重点实验室,郑州 450046;3.河南中医药大学中医药科学院,郑州 450046
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作者单位:1.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州 450046;2.河南省中医药防治呼吸病重点实验室,郑州 450046;3.河南中医药大学中医药科学院,郑州 450046
作者简介:
通讯作者:
中图分类号:R-33
基金项目:

Progress on mitochondrial injury in skeletal muscle induced by chronic obstructive pulmonary disease and treatment with traditional Chinese medicine

Author:

ZHAO Gaoyuan
ZHAO Gaoyuan
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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MIAO Yufang
MIAO Yufang
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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HOU Runsu
HOU Runsu
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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LI Kangchen
LI Kangchen
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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TIAN Yange
TIAN Yange
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046
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Affiliation:

1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046

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摘要:

骨骼肌功能障碍 ( skeletal muscle dysfunction, SMD) 是慢性阻塞性肺疾病 ( chronic obstructive pulmonary disease,COPD)的常见并发症,导致患者活动能力降低,严重影响其生活质量。线粒体损伤是 COPD 合并 SMD 的主要机制之一,线粒体的氧化应激、能量代谢障碍、自噬异常等是引起线粒体损伤的重要原因:线粒体 ROS 的生成增多导致氧化应激,引起线粒体生物合成减少、体密度降低和线粒体呼吸功能(RCR 评估)下降;线粒体膜电位降低、ATP 合成酶活性降低、线粒体膜通透性转换孔的过度开放导致线粒体能量代谢障碍;严重氧化应激和全身炎症均能触发线粒体自噬异常,加快其降解和清除。中医药在改善 COPD 患者运动能力,提高患者生活质量等方面具有明显优势。随着近年来中医药相关研究的深入,中医药对改善线粒体损伤治疗 COPD 合并 SMD 取得了一定进展。该文结合国内外相关文献,就线粒体损伤与 COPD 合并 SMD 关系及其中医药治疗进行总结,为进一步研究提供依据。

关键词:慢性阻塞性肺疾病;骨骼肌功能障碍;线粒体损伤;中医药

Abstract:

Skeletal muscle dysfunction (SMD) is a common complication of chronic obstructive pulmonary disease (COPD), which usually causes a decline in exercise activity and quality of life. Mitochondrial injury is one of the main mechanisms by which SMD coexists with COPD, and injury is mainly caused by oxidative stress, energy metabolism disorders, and abnormal autophagy. An increase in mitochondrial reactive oxygen species production leads to oxidative stress and decreased mitochondrial biosynthesis, volume density, and mitochondrial respiratory function (respiratory control ratio evaluation). Decreased mitochondrial membrane potential and ATP synthase activity and excessive opening of the mitochondrial membrane permeability transition pore may result in mitochondrial-mediated metabolic disorders. Severe oxidative stress and systemic inflammation can trigger abnormal mitochondrial autophagy and accelerate degradation and clearance of mitochondria. Traditional Chinese medicine ( TCM) has obvious benefits in improving exercise ability and quality of life in patients with COPD. With the in-depth study of TCM in recent years, TCM has been shown to improve mitochondrial injury after treatment of COPD-induced SMD. In this study, we reviewed the relevant literature and summarized the relationship between mitochondrial injury and COPD combined with SMD and treatment with TCM. This review may provide a basis for further research.

Key words:chronic obstructive pulmonary disease; skeletal muscle dysfunction; mitochondrial injury; traditional Chinese medicine

引用本文

赵高远,苗玉芳,侯润苏,李康沉,田燕歌.线粒体损伤与慢性阻塞性肺疾病骨骼肌功能障碍及中医药治疗进展[J].中国比较医学杂志,2022,32(2):133~137,144.

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收稿日期:2021-01-14
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在线发布日期: 2022-04-12
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