1.遵义医科大学口腔医学院,贵州 遵义 563000;2.贵州省普通高等学校口腔疾病研究特色重点实验室暨遵义市口腔疾病研究重点实验室,贵州 遵义 563000;3.贵州省普通高等学校微生物资源与药物开发特色重点实验室,贵州 遵义 563000; 4.口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,成都 610041
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ZHOU Xuedong
1. School of Stomatology, Zunyi Medical University, Zunyi 563000, China.4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 6100411. School of Stomatology, Zunyi Medical University, Zunyi 563000, China. 2. Special Key Laboratory of Oral Diseases Research, Higher Education Institution in Guizhou Province, Zunyi Key Laboratory of Oral Diseases Research, Zunyi 563000. 3. Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi 563000. 4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041
当今全球已迅速步入老龄化社会,老年人口迅速扩增。 伴随年龄增长,机体免疫系统发生着系列变化,即“免疫衰老”,导致各种感染的发生率和老年病的死亡率加剧,增加了各国对卫生医疗的需求。 牙周炎是口腔病原菌与免疫系统相互作用引起的牙周组织损伤,在老年人群中表现出发病率增加和组织破坏程度增加,严重影响老年群体的身心健康,增加医疗负担。 本文主要综述了衰老与免疫衰老对牙周炎的影响,尤其从免疫细胞方面(包括先天性免疫细胞和适应性免疫细胞)来阐述机体老化对牙周炎疾病的影响。
Currently, many countries have rapidly stepped into the aging society and the elderly population is growing sharply. The aging process is accompanied by a series of changes in the immune system, which is known as “immunosenescence” and leads to an increase in the incidence of various infections and mortality from geriatric diseases, increasing the demand for healthcare in all counties. Periodontitis is chronic inflammation of periodontal tissue caused by an interaction between pathogenic bacteria and host immune system, which has shown a rising trend in vulnerability and periodontal destruction in the elderly population. It seriously affects both physical and mental health of the elderly and increases the medical burden. This article reviews the effects of senescence and immunosenescence on periodontitis, especially the effects of aging on immune cells, which include innate immune cells and adaptive immune cells, on periodontitis.
姚燕子,胡 欢,王 倩,刘建国,周学东.免疫衰老影响牙周炎细胞免疫的研究进展[J].中国比较医学杂志,2022,32(2):116~125.
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