Leukemia is a kind of hematological malignance characterized by the clonal expansion of leukemic cells and has a high lethality. Paclitaxel is a natural anticancer drug that has been widely used in chemotherapy against multiple malignancies because of its unique anticancer effects. However, there are relatively few studies of paclitaxel use in the treatment of leukemia. This paper reviewed the researchs of paclitaxel in the treatment of leukemia.