毕节市第一人民医院,贵州 毕节 551700
R-33
The First People’s Hospital of Bijie, Bijie 551700, China
虎杖苷是从蓼科植物虎杖中分离的一种单体化合物,现代药理学研究表明,其具有多方面的药理活性,如抗血栓、抗动脉硬化、改善心肌损伤、抗休克以及调节糖脂代谢等。近年来研究发现虎杖苷还具有保护肝细胞、抗肝纤维化、改善肝细胞脂肪变性及抗肝癌等作用。 本文综述了虎杖苷在肝疾病方面的药理作用及机制,以期为其后续研究及开发利用提供参考。
Polydatin is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae). Modern pharmacological studies have indicated that polydatin has a variety of pharmacological activities, such as anti-thrombosis, anti-arteriosclerosis, improvement of myocardial damage, anti-shock and regulation of glucose and lipid metabolism. In recent years, studies have reported that polydatin also has anti-liver cancer and anti-liver fibrosis effects and protects hepatocytes and improves hepatocyte steatosis. This article reviews the pharmacological effects and mechanisms of polydatin in liver disease to provide a reference for its follow-up research, development and use.
邓 艳,刘 洪,吴新玉,成 蕾,贺 梅,王婷婷,叶林虎.虎杖苷的保肝作用研究进展[J].中国比较医学杂志,2021,31(9):136~140.
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