Objective To study the intervention effect of vascular endothelial growth factor (VEGF) inhibitors on diabetic retinopathy model rats and the hemodynamics of central retinal artery (CRA). Methods Of 40 specific-pathogen- free healthy male rats, 10 were randomly selected as the control group. The remaining 30 rats were successfully modeled and randomly divided into the model group ( normal saline), sterile citric acid group ( sterile citric acid) and VEGF inhibitor group ( bevacizumab) ( n= 10). The minimum diastolic velocity ( EDV) of the CRA was measured. Results Compared with the model group, the levels of EDV (31. 53±8. 42 / 47. 46± 10. 29 / 90. 26± 16. 55 mm/ s, F/ P= 14. 956 / 0. 001), peak systolic velocity ( PSV; 58. 92± 11. 37 / 84. 16± 14. 52 / 155. 57± 18. 67 mm/ s, F/ P= 21. 116 / 0. 001) and adiponectin were increased in the aseptic citric acid and VEGF inhibitor groups. In addition, the resistivity index (RI; 1. 12±0. 32 / 0. 85±0. 20 / 0. 68±0. 18, F/ P= 7. 046 / 0. 001), pulsatility index (PI; 1. 35±0. 35 / 0. 91±0. 22 / 0. 69±0. 12, F/ P= 8. 861 / 0. 001 ), hemorheological indicators, fasting blood glucose, VEGF, intercellular adhesion molecule 1 (ICAM-1), interleukin-1 (IL-1) and expression levels of Ras, Raf and extracellular signal-regulated kinase (ERK) were significantly decreased (P<0. 05). Compared with the aseptic citric acid group, the levels of EDV (47. 46±10. 29 / 90. 26± 16. 55 mm/ s, T/ P= 6. 945 / 0. 001), PSV (84. 16±14. 52 / 155. 57±18. 67 mm/ s, T/ P= 9. 548 / 0. 001) and adiponectin were increased in the VEGF inhibitor group. Furthermore, the RI ( 0. 85± 0. 20 / 0. 68± 0. 10, T/ P= 2. 404 / 0. 027), PI (0. 91±0. 22 / 0. 69±0. 12, T/ P= 2. 776 / 0. 012), hemorheological indicators, fasting blood glucose, VEGF, ICAM-1, IL- 1 and expression of Ras, Raf-1, and ERK were significantly decreased (P<0. 05). Conclusions VEGF inhibitors can improve the CRA hemodynamics and hemorheology indices of diabetic retinopathy model rats, reduce the levels of VEGF, ICAM-1 and IL-1β and inhibit angiogenesis.