Objective To explore the mechanism of bupleurum and scutellaria herb pairs and their effective active compounds and targets in the treatment of sinusitis. Methods The chemical components and their corresponding targets in the bupleurum-scutellaria drug pair were screened through the TCMSP database, and the relevant drug targets screened in the UniProt database and sinusitis disease targets screened in the Genecards database were intersected. The STRING platform was used to construct a target protein interaction action network. The Metascape platform was used to perform GO enrichment analysis and DAVID was used to perform KEGG enrichment analysis. Cytoscape 3. 8. 0 software was used to construct a component-target pathway network diagram and Autodock software was used for molecular docking of key targets and compounds to select the best binding target. Results Thirty-nine related compounds were screened out and the component and disease targets were intersected to obtain 92 targets. The main active components were quercetin, kaempferol, wogonin, baicalein, acacetin, and sitosterol. The core genes were TP53, AKT1, MAPK1, PIK3CG, PTGS2, HSP90AA1, and six others. In molecular docking, the energy of the main active components and major targets was lower than -5 kcal / mol. Conclusions Through network pharmacology and the molecular docking system, the potential effective components and mechanism of bupleurum-scutellaria baicalensis for treatment of sinusitis were identified, which provides a basis for future in-depth research of the mechanism.