1.广州中医药大学第三临床医学院,广州 510405; 2.广州中医药大学第三附属医院,广州 510405; 3.暨南大学,广州 510632
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1.the Third Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China. 2. the Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405. 3. Jinan University, Guangzhou 510632
膝骨关节炎可分为原发性和继发性,病因不明,动物实验是进一步探索其发病机制和防治的重要手段,基于国内外相关文献,经典的造模方式可分为人工诱导和自发造模,与本病相关的主流中医证候是肾阳虚、血瘀和寒湿证,分别对应三种造模方式,而病证结合的动物模型将是未来研究的主流趋势,结合笔者多种造模方式的经验,对其做一综述以供参考。
Knee osteoarthritis can be divided into primary and secondary types, but the etiology of these types is unknown. Animal experiments enable further exploring the pathogenesis and prevention of knee osteoarthritis. The related literature suggests that classic models can be divided into artificial induction and spontaneous modeling. The associated mainstream traditional Chinese medicine syndromes for this disease are kidney yang deficiency, blood stasis and cold dampness syndrome, which correspond to three modeling method . Animal models that combine these diseases and syndromes will be important for future research. These models, combined with the author’s practical experience in multiple modeling method , provide a review for reference.
杨 威,郭斯印,易志勇,黄旭东,韩清民,张荣华.膝骨关节炎病证结合动物模型的研究进展[J].中国比较医学杂志,2021,31(3):139~143.
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