Calcific aortic valve disease is an active progressive disease characterized by inflammation, fibrosis and calcification, but the exact pathologic mechanism is unclear. At present, research is mainly conducted in animal models. Those animal models that best simulate the disease process help to clarify the mechanisms of the occurrence and development of the disease, and may lead to the identification of effective clinical treatments. In this paper, we reviewed and evaluated the mouse model of calcific aortic stenosis to provide a reference for the selection of other animal models of calcified valvular disease.