免疫缺陷小鼠和人源化小鼠模型在干细胞质量控制中的应用
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中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学 重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京 100021

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R-33


Applications of immunodeficient and humanized mice in stem cell quality control
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  • SHI Guiying

    SHI Guiying

    Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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  • BAI Lin

    BAI Lin

    Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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Affiliation:

Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China

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    摘要:

    干细胞具有自我更新和多向分化的能力,在治疗糖尿病、脑损伤、急性心梗等疾病的治疗中有着巨大的潜力。 由于干细胞产品种类繁多、批次差异性大、性质复杂,因此干细胞产品临床前的质量控制尤为重要。 干细胞作为活性外源物质具有免疫原性,免疫缺陷小鼠和人源化小鼠在干细胞质量控制中发挥极大作用。 本文综述了干细胞的免疫学特性、总结了常用的免疫缺陷和人源化小鼠模型,概述了免疫缺陷和人源化小鼠模型在干细胞质量控制中的应用,以期为干细胞质量控制标准化提供资料和信息。

    Abstract:

    Stem cells self-renew, undergo multidirectional differentiation, and have great therapeutic potential for diabetes, brain injury, and acute myocardial infarction as examples. There are many types of stem cell products and many variations among batches. Therefore, quality control is particularly important for stem cell products before clinical use. Stem cells are immunogenic as living exogenous cells, and immunodeficient and humanized mice play an important role in stem cell quality control. Here, we review stem cell immunogenicities, summarize the commonly used immunodeficient and humanized mice, and outline the model applications of stem cell quality control to provide for a reference for stem cell quality control.

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石桂英,白 琳.免疫缺陷小鼠和人源化小鼠模型在干细胞质量控制中的应用[J].中国比较医学杂志,2020,30(10):132~137.

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  • 收稿日期:2020-07-07
  • 在线发布日期: 2020-11-25
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