Bone metastasis is a common complication of lung cancer, and patient survival rate increases its risk. Animal models of bone metastasis are useful to investigate lung cancer bone metastasis. An explanation of the pathophysiology of lung cancer bone metastasis is important for medical research in lung cancer. In this paper we review domestic and foreign reports on the research status of animal models of lung cancer bone metastasis and discuss lung cancer cell lines, experimental animal strains, model building method , and evaluation method in detail. It is hoped that this paper will be an important reference for the study of lung cancer.