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首页 > 过刊浏览>2020年第30卷第9期 >96-102. DOI:10. 3969 / j.issn.1671-7856. 2020. 09. 018
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干细胞治疗2型糖尿病及其并发症的研究进展
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1.中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类 疾病比较医学重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,北京 100021; 2.北京师范大学生命科学学院,北京 100875


Research progress on stem cell therapy for type 2 diabetes mellitus and associated complications
Author:
  • LI Xinyue 1

    LI Xinyue

    Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China.
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  • LI Qian 2

    LI Qian

    Key Lab of Cell Proliferation and Regulation Biology of the Ministry of Education, Institute of Cell Biology, Beijing Normal University, Beijing 100875
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  • SHI Guiying 1

    SHI Guiying

    Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China.
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  • HUANG Yiying 1

    HUANG Yiying

    Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100022, China.
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  • LEI Xuepei 1

    LEI Xuepei

    Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100023, China.
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  • BAI Lin 1

    BAI Lin

    Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100024, China.
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Affiliation:

1. Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China. 2. Key Lab of Cell Proliferation and Regulation Biology of the Ministry of Education, Institute of Cell Biology, Beijing Normal University, Beijing 100875

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    摘要:

    2 型糖尿病是我国高发的慢性疾病,发生机制为机体对胰岛素抵抗伴随胰岛β细胞功能缺陷引起的胰岛素相对缺乏。2型糖尿病为进展性疾病,随自然病程发展对外源性血糖控制的依赖增大、导致多组织器官病变,引起多种继发性并发症发生。传统治疗对药物依赖性大,且口服药物和外源性胰岛素只能暂时维持血糖或暂时改善胰岛素敏感性,无法根本治愈。随着干细胞研究的深入,干细胞的自我更新和定向分化潜能为修复受损组织恢复胰岛功能进而治疗糖尿病开辟了新思路。本文从不同类型干细胞治疗2型糖尿病的方法、优缺点及研究进展进行综述,希望对研究糖尿病和糖尿病并发症致病机理、应用干细胞移植技术恢复胰岛素独立性以及建立干细胞安全性和有效性的评价提供一定参考。

    Abstract:

    Type 2 diabetes mellitus (T2DM) is a chronic disease with a high incidence in China. It occurs due to a relative lack of insulin because of insulin resistance and islet β-cell dysfunction. Type 2 diabetes is a progressive disease, and its dependence on exogenous glycemic control increases over the development of its natural course, leading to multiple tissue and organ diseases and causing various secondary complications. Traditional treatment relies heavily on drugs, yet oral drugs and exogenous insulin can only temporarily maintain blood glucose or temporarily improve insulin sensitivity; however, the disease cannot be cured fundamentally. With the deepening of stem cell research, the self-renewal and directional differentiation potential of stem cells have opened up new ideas for repairing damaged tissues and restoring islet function, thus treating diabetes. This article reviews the method, advantages, disadvantages, and research progress of different types of stem cells in the treatment of type 2 diabetes. We hope to provide reference for the study of the pathogenesis of diabetes and its complications, and for applying stem cell transplantation technology to restore insulin independence, as well as to establish an evaluation of the safety and effectiveness of stem cell therapy.

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李欣悦,李 倩,石桂英,黄艺滢,雷雪裴,白 琳.干细胞治疗2型糖尿病及其并发症的研究进展[J].中国比较医学杂志,2020,30(9):96~102.

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历史
  • 收稿日期:2020-01-17
  • 在线发布日期: 2020-10-26
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