1.河南中医药大学,中医药科学院,郑州 450046; 2.河南中医药大学第一附属医院,药学部 郑州 450000
1.Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Department of Pharmacy, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000
2019 冠状病毒病(coronavirus disease 2019, COVID-19)是一种新的传染病,由严重急性呼吸综合征冠状病毒 2(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)引起的一种呼吸道疾病,在全球范围内暴 发流行,其高传染率和死亡率威胁全球。 为加速 COVID-19 急性传染病的研究,多种实验动物被调查研究,结果发 现非人灵长类、小鼠、叙利亚仓鼠、雪貂和家猫都能支持 SARS-CoV-2 的复制,其中有些动物显示了不同程度的病理 变化及临床症状。 COVID-19 动物模型在研究 SARS-CoV-2 传播、发病机制及测试药物和疫苗等具有重要意义。 本 文对近半年来 COVID-19 动物模型制备情况及各种动物模型的特征与使用范围进行总结分析,为将来优化及选择 COVID-19 动物模型提供理论参考依据。
COVID-19 is a respiratory disease caused by a new coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first confirmed COVID-19 case, it has spread as a pandemic globally in a short time, Results ing in a contagion with numerous deaths. To accelerate research on COVID-19 systematically, a variety of laboratory animals have been investigated, indicating that non-human primates, mice, Syrian hamsters, ferrets, and domestic cats support replication of SARS-CoV-2. Among them, some animals present different degrees of pathological changes and clinical symptoms in response to SARS-CoV-2 infection. COVID-19 animal models would be of great significance to study the mechanisms of SARS-CoV-2 transmission ad pathogenesis, as well as testing drugs and vaccines. This is a summary of the preparation of COVID-19 animal models in the past 6 months. We investigated the characteristics and scope of each animal model to provide a theoretical reference for future optimization and selection of COVID-19 animal models for specific purposes.
苗晋鑫,宋韶鹤,王 峥,苗明三. COVID-19 动物模型研究进展[J].中国比较医学杂志,2020,30(7):120~126.
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