Abstract:Animal models of human disease have an important role in elucidating the pathogenesis of disease and exploring therapeutic method in basic medicine and pre-clinical research. Compared with rodents, there are many advantages to the use of pigs as animal models of disease because of their anatomy, physiology, nutrition metabolism, and for ethical reasons. A variety of human disease model pigs have been produced using method such as gene editing and somatic cell nuclear transfer. This paper reviews the research progress made on pig models in the fields of diabetes, cardiovascular disease, neurodegenerative disease, genetic disease, and tumors in recent years, and discusses the phenotypic instability of different models that could not accurately simulate human disease. We discuss important references for understanding and promoting the application of pigs as animal models of human disease.