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首页 > 过刊浏览>2019年第29卷第8期 >142-148. DOI:10.3969/j. issn. 1671 -7856. 2019. 08. 023
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干细胞治疗帕金森病的研究进展
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(中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,北京 100021)

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R-34


Research progress in stem cell therapy for Parkinson’s disease
Author:
  • LYU Ying

    LYU Ying

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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  • BAI Lin

    BAI Lin

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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  • QIN Chuan

    QIN Chuan

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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Affiliation:

(Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China)

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    摘要:

    帕金森病是一种中脑黑质多巴胺能神经元渐进性变性死亡从而导致黑质-纹状体通路受损的中枢神经系统退行性疾病,临床主要的治疗方式为药物和手术,但均只能短期缓解症状且后期副作用大,无法达到治愈的效果?干细胞具有自我更新能力和多向分化潜能,干细胞移植可在损伤组织内进行神经再生与修复,为帕金森病的治疗带来了曙光?本文从干细胞取材?不同类型干细胞治疗帕金森病的方法?疗效和优缺点等方面进行比较分析,总结了干细胞治疗帕金森病的几种可能的作用机制,希望对干细胞治疗帕金森病的机制研究?细胞类型和移植方式的选择及临床试验等提供一定的帮助?

    Abstract:

    Parkinson’ s disease is a degenerative disease of the central nervous system in which dopaminergicneurons in the substantia nigra gradually degenerate and are lost, leading to damage of the substantia nigra-striatumpathway. The main clinical treatments for this disease are drugs and surgery, but both only relieve short-term symptoms andhave many side effects. Moreover, neither results in a cure. Stem cells have the capacity for self-renewal and a multidirectionaldifferentiation potential. Stem cell transplantation can result in nerve regeneration and restoration within thedamaged tissue, bringing hope for a possible treatment for Parkinson’ s disease. This article compares and analyzes theseparation methods, modes of transplantation, efficacy, and advantages and disadvantages of different types of stem cells inthe treatment of Parkinson’s disease. It also summarizes possible mechanisms by which stem cells could provide a treatmentfor Parkinson’s disease. This article should aid the selection of cell types and methods of transplantation for use in clinical trials.

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引用本文

吕颖,白琳,秦川.干细胞治疗帕金森病的研究进展[J].中国比较医学杂志,2019,29(8):142~148.

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历史
  • 收稿日期:2018-12-26
  • 在线发布日期: 2019-09-12
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