There are approximately 240 million patients with chronic hepatitis B virus (HBV) in the world. Despite the production of HBV vaccines and antiviral drugs, HBV still remains a serious threat as an infectious disease to human health. Due to the lack of an ideal animal model, the study of HBV is limited. This review was to analyze in accordance with existing HBV animal model, to explore the differences in applications of various models regarding their etiology, pathology and pathophysiology. thus, to provide a reference for researchers in future HBV research to better use the resources.