Objectives To observe the anesthetic effects of an improved anesthetic method on goat by comparing with the original method, and to provide theoretical and practical reference for anesthesia during the establishment of goat models. Methods A total of 72 goats were selected to make tibial fracture models, 36 were enrolled as group A and others as group B. The group A was injected with Sumianxin and diazepam. The group B was injected with Sumianxin, diazepam and pumped propofol by intravenous pump. The times of animal struggle, total dose of additional Sumianxin, death rate, and recovery time were evaluated. Results The death rate of group A was 16.67% and there was no death in the group B. The times of struggle, the total dose of additional Sumianxin and the recovery time of the group A were higher than group B, showing a significant difference (P<0.05). Conclusions The improved anesthetic method can decrease the times of goat struggle times, reduce the dose of anaesthetics, and lower the death rate.