Objective To study the effect of Interleukin-22 (IL-22) on murine asthmatic airway inflammation and airway remodeling, observe the effect of budesonide on IL-22 of asthmatic mouse model, explore the mechanism of budesonide in the treatment of asthma. Methods Ovalbumin(OVA) was used as an allergen to sensitize and challenge the mice. 24 female specific-free (SPF) BALB/c mice aged four weeks were randomly divided into 3 groups:control group, asthma group and budesonide treatment group (BUD group). For Histopathological Examination, HE staining was used to measure the inflammation scores, AB-PAS staining was used to measure the hyperplasia of goblet cells and mucin. Enzyme-linked immunosorbent assay(ELISA) was used to analyze IL-22 levels in bronchoalveolar lavage fluid (BALF). Quantitative Real-time PCR was performed to analyze the effects of budesonide on IL-22 mRNA levels in lung tissue. Results The inflammation scores of asthma group were elevated compared with the control group. An overall change towards less severe asthmatic airway inflammation by the end of the trial was observed in the BUD group. IL-22 levels in BALF were significant decreased after the treatment of budesonide, the mRNA levels of IL-22 were obviously decreased in BUD group, too. A significant positive correlation was observed between the mRNA levels of IL-22 and airway inflammation. Conclusions The increasing IL-22 secretion can lead to the occurrence of airway inflammation of asthma. Budesonide can inhibit the expression of IL-22, thereby Budesonide could inhibit the development of airway inflammation of asthma.