皮肤致敏试验替代方法的研究进展
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深圳市药品检验研究院重点学科团队建设项目。


Research progress of alternative in vitro methods to evaluate skin sensitization
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    摘要:

    皮肤致敏(过敏性接触性皮炎)是皮肤接触某些小分子化合物而引起的迟发性超敏反应。经典的检测化学物接触致敏性的方法是通过动物试验来检测,鉴于欧盟于2013年颁布全面禁止化妆品动物试验的规定,替代试验将来是化学品/化妆品致敏研究的主要趋势,本文综合近年的国内外文献,对现行的通过OECD认证的和正在开展研究的皮肤致敏替代试验,如LLNA、DPRA、KeratinoSens TM、h-CLAT试验等进行综合论述和评估,为未来体外替代试验能够客观、公正的对致敏结果评估提供参考。

    Abstract:

    Skin sensitization (allergic contact dermatitis, ACD), is a serious condition caused by small reactive molecules and is characterized by a delayed-type hypersensitivity. Animal tests were usually used in the evaluation of sensitizing potential of chemical substances in the past. However, there is an increasing interest from the public for reducing and ultimately replacing animal tests. The European Union (EU) has posed a ban on animal testing of cosmetic ingredients that includes skin sensitization since 2013. Therefore, alternative in vitro tests are the main tendency in chemical substances and cosmetic sensitizing potential research in the future. In this study, different kinds of in vitro test methods that were adopted by OECD or on research(LLNA, DPRA, KeratinoSens TM, h-CLAT)were reviewed through recent years literature, comprehensive introduction and evaluation were made to obtain reliable hazard and potency information on potential skin sensitizers.

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陈宁,王平,冼静雯,谢天柱,秦美容,李俊鹏,鲁艺,王晓炜,石海宁,龙绍蓉.皮肤致敏试验替代方法的研究进展[J].中国比较医学杂志,2016,26(12):85~90.

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  • 最后修改日期:2016-06-14
  • 在线发布日期: 2016-12-20
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