复杂性状遗传CC小鼠与精准医学研究
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国家自然科学基金(81573094,81372928);中央科研院所基本业务费(2016ZX310042)。


Collaborative Cross mice and precision medicine
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    摘要:

    生物组学技术在生物学、医学上的转化应用,为精准的个体化预防、诊断、治疗提供了关键性的技术体系,精准医学模式应运而生。实验动物学研究是疾病发病机制研究转化到临床不可或缺的手段。为应对目前严重危害人类疾病的复杂性、多样性特点,2002年国际复杂性状联盟(Complex Trait Consortium, CTC)倡议研发建立新的小鼠遗传资源库;通过不同纯系小鼠品系间的杂交创建小鼠复杂性状遗传资源库(Collaborative Cross mice, CC小鼠)。随着原始亲本小鼠(founder)选定、杂交品系的繁殖,CC小鼠在检测小鼠表型、疾病易感性、疾病发生发展及预后与遗传因素的关系方面进行了系列的尝试。文中将就CC小鼠在疾病发生发展及药物评价个体化研究中的应用做一简要介绍。

    Abstract:

    The individual variability should be considered in precision medicine-prevention and treatment strategies. Medical research using genomics, proteomics, metabolomics, systems analyses, and other modern tools has made big progress.In 2002, the members of the Complex-Trait Consortium proposed to develop a new mouse genetics resource called the Collaborative Cross (CC). The CC is a genetic reference panel of recombinant inbred lines of mice, designed for the dissection of complex traits and gene networks.It will provide a powerful measure for functional studies of biological networks, which will be essential to understand the intricacies of disease processes.

    参考文献
    [1] Churchill GA,Airey DC,Allayee H,et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics[J]. 2004,36(11):1133-1137.
    [2] Cyranoski D.China embraces precision medicine on a massive scale[J]. Nature News, 2016.529(7584)9-10.
    [3] 方福德, 复杂疾病遗传分析的现状、问题和展望[J]. 中国医学科学院学报, 2009,31(6):661-663.
    [4] Threadgill DW,Churchill GA.Ten years of the Collaborative Cross[J].Genetics,2012,190(2):291-294.
    [5] Ram R, Mehta M, Balmer L, et al. Rapid identification of major-effect genes using the collaborative cross[J]. Genetics, 2014,198(1):75-86.
    [6] Kelada SN, Aylor DL, Peck BC, et al.Genetic analysis of hematological parameters in incipient lines of the collaborative cross[J]. G3(Bethesda), 2012,2(2):157-165.
    [7] Levy R, Mott RF, Iraqi FA, et al. Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture[J]. BMC Genomics, 2015,16(1):1013.
    [8] Atamni HJ, Mott R, Soller M, et al.High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population[J]. BMC Genet, 2016,17:10.
    [9] Weerasekera LY, Balmer LA, Ram R, et al. Characterization of Retinal Vascular and Neural Damage in a Novel Model of Diabetic Retinopathy[J]. Investigative Ophthalmology & Visual Science, 2015,56(6):3721-3730.
    [10] Rutledge H, Aylor DL, Carpenter DE, et al. Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation in murine lung[J]. Genetics, 2014,198(2):735-745.
    [11] Chow CY, Wang X, Riccardi D, et al. The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse[J]. Plos Genetics, 2015,11(2):e1004924..
    [12] Ferguson B, Ram R,Handoko HY, et al.Melanoma susceptibility as a complex trait:genetic variation controls all stages of tumor progression[J]. Oncogene, 2015,34(22):2879-2886.
    [13] Lore NI, Iraqi FA, Bragonzi A.Host genetic diversity influences the severity of Pseudomonas aeruginosa pneumonia in the Collaborative Cross mice[J]. BMC Genet, 2015,16:106.
    [14] Vered K, Durrant C, Mott R, et al. Susceptibility to klebsiellapneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points[J]. Bmc Genomics, 2014,15(1):25-46.
    [15] Gralinski LE, Ferris MT, Aylor DL, et al. Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross[J].Plos Genetics, 2015,11(10):e1005504.
    [16] Durrant C, Tayem H, Yalcin B, et al. Collaborative Cross mice and their power to map host susceptibility to infection. 2011[J].Genetics,2012,190(2):389-401.
    [17] Gelinas R., Chesler EJ, Vasconcelos D, et al.A genetic approach to the prediction of drug side effects:bleomycin induces concordant phenotypes in mice of the collaborative cross[J]. Pharmacogenomics & Personalized Medicine, 2011,4:35-45.
    [18] Crowley JJ, KimY, Lenarcic AB, et al. Genetics of adverse reactions to haloperidol in a mouse diallel:a drug-placebo experiment and Bayesian causal analysis[J]. Genetics, 2013,196(1):321-347.
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杜朋,陈孟毅,李程程,樊飞跃,孟爱民.复杂性状遗传CC小鼠与精准医学研究[J].中国比较医学杂志,2016,26(8):30~35.

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  • 最后修改日期:2016-07-05
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