Tissues and organs generate angiogenesis under the stimulation of angiogenic factors in physiological or pathological conditions. Multiple signal pathways including VEGF, Notch, Wnt/β-catenin, Ang1(2)/tie2 and PIK-Akt etc. have effects on various stages of angiogenesis. VEGF exerts irreplaceable effects on the whole process of angiogenesis through multiple signal pathways. Over the past few years, new progress has been made in the researches of mechanisms regulating angiogenesis through VEGF-related signal pathways both at home and abroad. These findings provide us new theoretical basis for clarification of the pathogenesis of many diseases and clinical drug development. In this article we will summarize the recent research progress in this field, hoping to provide new possibilities for the treatment of angiogenesis-related diseases.