+高级检索
首页 > 过刊浏览>2015年第25卷第10期 >71-74. DOI:10.3969.j.issn.1671.7856.2015.010.017
PDF HTML阅读 XML下载 导出引用 引用提醒
SAMHD1限制HIV/SIV病毒复制功能研究的最新进展
作者:
基金项目:

国家十二五科技重大专项课题(2013ZX10004608-003和2012ZX10004501-001)。


The updated research progress of SAMHD1 on the restriction of HIV/SIV replication
Author:
  • PENG Ling-juan

    PENG Ling-juan

    Comparative Medicine Center, Peking Union College(PUMC)&Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Dieases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State administration of Traditional Chinese medicine, Beijing 100021, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • CONG Zhe

    CONG Zhe

    Comparative Medicine Center, Peking Union College(PUMC)&Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Dieases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State administration of Traditional Chinese medicine, Beijing 100021, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • WEI Qiang

    WEI Qiang

    Comparative Medicine Center, Peking Union College(PUMC)&Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Dieases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State administration of Traditional Chinese medicine, Beijing 100021, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • 摘要
    • | |
  • 访问统计
    • |
  • 参考文献 [35]
    • | | | |
  • 文章评论
    摘要:

    SAMHD1是宿主限制性天然免疫分子,主要在髓系细胞及静息CD4+T细胞中表达,通过降低胞内dNTP水平限制HIV-1的复制和感染。近来研究发现SAMHD1还能够促进HIV/SIV病毒的基因重组、降解病毒基因组RNA以及抑制病毒在细胞间的传播,在病毒的感染、复制、包装、传播等整个生命过程中都发挥着一定的作用。目前这一天然抗病毒蛋白分子已经成为HIV研究领域的新热点, 本文将就SAMHD1抗HIV病毒研究的最新进展做一综述。

    关键词:SAMHD1;HIV-1;Vpx
    Abstract:

    The host protein SAMHD1 has been identified as the first mammalian deoxynucleoside triphosphate triphosphohydrolase(dNTPase), which blocks the infection of HIV-1 in non-cycling immune cells. SAMHD1 protein is highly expressed in human myeloid-lineage cells and resting CD4+T lymphocytes, which restricts HIV-1 replication by hydrolyzing the cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA(cDNA) synthesis. Recent studies have revealed that SAMHD1 plays an important role in virus whole life by promoting HIV-1 genome recombination, degenerating viral genome RNA and restricting virus transmission between cells. In this review, these progress on SAMHD1 research are summarized and the mechanisms by which SAMHD1 mediates retroviral restriction are analyzed.

    Key words:SAMHD1;HIV-1;Vpx
    参考文献
    [1] Welbourn S, Miyaqi E, White TE, et al. Identification and characterization of naturally occurring splice variants of SAMHD1[J]. Retrovirology, 2012, 9:86.
    [2] Crow YJ, JH Livingston. Aicardi-Goutieres syndrome:an important Mendelian mimic of congenital infection[J]. Dev Med Child Neurol, 2008, 50(6):410-416.
    [3] 李佩璐,陈倩倩,张弛宇. 髓系单核细胞来源的HIV-1限制因子-SAMHD1[J]. 动物学研究, 2012,33(5):537-541.
    [4] Baldauf HM, Pan X, Erikson E, et al. SAMHD1 restricts HIV-1 infection in resting CD4(+)T cells[J]. Nat Med, 2012, 18(11):1682-1687.
    [5] Laguette N, Sobhan B, Casartelli N, et al. SAMHD1 is the dendritic- and myeloid-cell specific HIV-1 restriction factor counteracted by Vpx[J]. Nature, 2011, 474(7353):654-657.
    [6] Wu L. SAMHD1 knockout mice:modeling retrovirus restriction in vivo[J]. Retrovirology, 2013, 10:142.
    [7] Rehwinkel J, Maelfait J, Bridgeman A, et al. SAMHD1-dependent retroviral control and escape in mice[J]. EMBO J, 2013, 32(18):2454-2462.
    [8] Behrendt R, Schuman T, Gerbaulet A, et al. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response[J]. Cell Rep, 2013, 4(4):689-696.
    [9] Zhang R, Bloch N,Nquyen LA, et al. SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells[J]. PLoS One, 2014, 9(2):e89558.
    [10] Gao L, Hanson MN, Balakrishnan M, et al. Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect[J]. J Biol Chem, 2008, 283(14):9196-9205.
    [11] Operario DJ, BalakrishmanM, Bambara RA, et al. Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer[J]. J Biol Chem. 2006, 281(43):32113-32121.
    [12] Onafuwa-Nuga A, Telesnitsky A. The remarkable frequency of human immunodeficiency virus type 1 genetic recombination[J]. Microbiol Mol Bio Rev, 2009, 73(3):451-480.
    [13] Jetzt AE, Yu H, Klarmann GJ, et al. High rate of recombination throughout the human immunodeficiency virus type 1 genome[J]. J Virol, 2000, 74(3):1234-1240.
    [14] Zhuang J, Jetzt AE, Sun G, et al. Human immunodeficiency virus type 1 recombination:rate, fidelity, and putative hot spots[J]. J Virol, 2002, 76(22):11273-11282.
    [15] Wisniewski M, Balakrishnan M, Palaniappan, et al. The sequential mechanism of HIV reverse transcriptase RNase H[J]. J Biol Chem, 2000, 275(48):37664-37671.
    [16] Gao L, Balakrishnan M, Roques BP, et al. Insights into the multiple roles of pausing in HIV-1 reverse transcriptase promoted strand transfer[J]. J Biol Chem, 2007, 282(9):6222-6231.
    [17] Nquyen LA, Kim DH, Daly MB, et al. Host SAMHD1 Protein Promotes HIV-1 Recombi-nation in Macrophages[J]. J Biol Chem, 2014, 289(5):2489-2496.
    [18] Ryoo J, Oh C, Choi J, et al. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction[J]. Nat Med, 2014, 20(8):936-941.
    [19] Beloglazova N, Flick R, Tchiqvintsev A, et al. Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction[J]. J Biol Chem, 2013, 288(12):8101-8110.
    [20] Goncalves A, Kavayel E, Rice GI, et al. SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutieres syndrome-associated mutations[J]. Hum Mutat, 2012, 33(7):1116-1122.
    [21] Goldstone DC, Ennis-Adeniran V, Hedden JJ, et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase[J]. Nature. 2011, 480(7377):379-382.
    [22] Powell RD, Holland PJ, Hollis T, et al. Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase[J]. J Biol Chem. 2011, 286(51):43596-43600.
    [23] White TE, Tuzova M, Valle-Casuso JC, et al. The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation[J]. Cell Host Microbe, 2013, 13:441-451.
    [24] Descours B, Cribier A, Chable-Bessia C, et al. SAMHD1 restricts HIV-1 reverse transcrip-tion in quiescent CD4(+) T-cells[J]. Retrovirology, 2012, 9:87.
    [25] Ayinde D, Casartelli N, Schwartz O. Restricting HIV the SAMHD1 way:through nucleo-tide starvation[J]. Nat Rev Microbiol, 2012, 10(10):675-680.
    [26] Cuadrado E, Jansen MH, Anink J, et al. Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome[J]. Brain, 2013, 136(1):245-258.
    [27] Dragin L, Anh Nguyen L, Lahouassa H, et al. Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply[J]. Retrovirology, 2013, 10(1):30.
    [28] 美国科学家首次拍摄HIV在人体内扩散过程[J]. 生物医学工程与临床,2009,13(3):217.
    [29] Thomas T. Murooka, Maud Deruaz, Francesco Marangoni, et al. HIV-infected T cells are migratory vehicles for viral dissemination[J]. Nature, 2012, 10490(7419):283-287.
    [30] Groot F, S Welsch, QJ Sattentau. Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses[J]. Blood, 2008, 111(9):4660-4663.
    [31] Blanchet F, Moris A, Mitchell JP, et al. A look at HIV journey:from dendritic cells to infection spread in CD4(+) T cells[J]. Curr Opin HIV AIDS, 2011, 6(5):391-397.
    [32] Puigdomenech I, Casartelli N, Porrot F, et al. SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells[J]. J Virol, 2013, 87(5):2846-2856.
    [33] Chauveau L, Puigdmenech I, Ayinde D, et al. HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells[J]. Retrovirology, 2015, 12(1):2.
    [34] Bloch N, O'Brien M, Norton TD, et al. HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx[J]. AIDS Res Hu Retroviruses. 2014, 30(2):195-203.
    [35] Sunseri N, O'Brien M, Bhardwai N, et al. Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells[J]. J Virol, 2011, 85(13):6263-6274.
    相似文献
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

彭灵娟,丛喆,魏强. SAMHD1限制HIV/SIV病毒复制功能研究的最新进展[J].中国比较医学杂志,2015,25(10):71~74.

复制
分享
文章指标
  • 点击次数:2089
  • 下载次数: 1462
  • HTML阅读次数: 0
  • 引用次数: 0
历史
  • 最后修改日期:2015-08-18
  • 在线发布日期: 2015-11-04
您是第8851494 位访问者
版权所有:中国比较医学杂志 主管单位：中国科学技术协会 主办单位：中国实验动物学会 中国医学科学院医学实验动物研究所
地址：北京市朝阳区潘家园南里5号 邮 编 ：100021 电话：010-67779337 E-mail:bjb@cnilas.org
技术支持：北京勤云科技发展有限公司
防诈骗提示！请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭