P2X3受体在糖尿病神经痛动物模型中的研究进展

doi:10.3969.j.issn.1671.7856. 2015.005.015

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P2X3受体在糖尿病神经痛动物模型中的研究进展
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                        10.3969.j.issn.1671.7856. 2015.005.015
                    
作者:
                        魏骏骏魏骏骏
浙江中医药大学第三临床医学院, 杭州 310053
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寿升芸寿升芸
浙江中医药大学第三临床医学院, 杭州 310053
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何晓芬何晓芬
浙江中医药大学第三临床医学院, 杭州 310053
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蒋永亮蒋永亮
浙江中医药大学第三临床医学院, 杭州 310053
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方剑乔方剑乔
浙江中医药大学第三临床医学院, 杭州 310053
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基金项目:国家自然科学基金(81303039);教育部高等学校博士学科点专项科研基金(20133322120001);浙江省博士后基金(BSH1302083);浙江省高校重中之重一级学科(中医学)建设经费(浙教高科[2012]80号)。

Progress of animal experimental research on P2X3 receptors in diabetes mellitus

Author:

WEI Jun-jun
WEI Jun-jun
The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
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SHOU Sheng-yun
SHOU Sheng-yun
The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
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HE Xiao-fen
HE Xiao-fen
The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
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JIANG Yong-liang
JIANG Yong-liang
The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
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FANG Jian-qiao
FANG Jian-qiao
The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
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摘要:

糖尿病神经痛(diabetic neuropathic pain, DNP)作为临床上最常见的并发症之一, 极大地影响了患者的生活质量, 目前发病机制尚不明确, 缺少有效的治疗方法。DNP与周围感觉神经兴奋性增强有关, 涉及多种离子通道、受体表达、功能上调, 已有研究表明P2X3受体参与DNP等多种神经病理痛的痛觉形成、传导和调节, 本文将围绕DNP模型的建立及P2X3受体在DNP模型中的作用予以综述。

关键词:P2X3受体;糖尿病;神经痛;糖尿病神经痛

Abstract:

Diabetic neuropathic pain(DNP)is one of the most common complications in clinical, which influenced patients’ daily functions greatly, without clear mechanisms and effective methods. P2X3 receptors play a pivotal role in the formation, transmission and conduction of pain under neuropathic pain models, associated with peripheral sensory nerve excitability enhancement. This paper focuses on the establishment of DNP models, and the effects of P2X3 receptors in diabetes mellitus.

Key words:P2X3 receptors;Diabetes;Neuropathic pain;Diabetic neuropathic pain

参考文献

[1] World Health Organization. Fact sheet N°312.Available from http://www.who.int.Accessed 13 January 2013.

[2] Candrilli SD, Davis KL, Kan HJ, et al. Prevalence and the associated burden of illness of symptoms of diabetic peripheral neuropathy and diabetic retinopathy[J]. J Diabetes Complications, 2007, 21(5): 306-314.

[3] Xu GY, Li G, Liu N, et al. Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats[J]. Mol Pain, 2011, 7: 60.

[4] RaafatK, Aboul-ElaM, El-LakanyA. Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model[J]. Arch Pharm Res, 2014.

[5] RaafatK, SamyW. Amelioration of Diabetes and Painful Diabetic Neuropathy by Punicagranatum L. Extract and Its Spray Dried BiopolymericDispersions[J]. Evid Based Complement Alternat Med, 2014, 2014:180495.

[6] Jianbo L, Chengya W, Jiawei C, et al. The role of IGF-1 gene expression abnormality in pathogenesis of diabetic peripheral neuropathy[J]. Chin Med Sci J, 2002, 17(4): 204-209.

[7] 杨明华, 柴可夫, 杨苏蓓. 四氧嘧啶致糖尿病大鼠模型血糖稳定性考察[J]. 中国比较医学杂志, 2006, 08:482-484.

[8] KangJ, Dai XS, Yu TB, et al. Glycogen accumulation in renal tubules, a key morphological change in the diabetic rat kidney[J]. ActaDiabetol, 2005, 42(2): 110-116.

[9] Lenzen S. The mechanisms of allxan- and strptozotcin-induced diabetes[J]. Diabetologia, 2008, 51: 216-226.

[10] Jafarnejad A, Bathaie SZ, Nakhjavani M, et al. Effect of spermine on lipid profile and HDL functionality in the streptozotocin-induced diabetic rat mode[J]l. Life Sci 2008, 82, 301-307.

[11] 胡玉焕, 宁亚功, 肖燕. 高热量饮食联合链脲佐菌素建立2型糖尿病大鼠模型的影响因素[J]. 江西中医学院学报, 2013, 01:70-73.

[12] 党江坤, 吴艳, 曹红, 等.Ⅱ型糖尿病神经病理性痛大鼠模型的建立[J].中国疼痛医学杂志, 2012, 04:234-237.

[13] Gao F, Zheng ZM. Animal models of diabetic neuropathic pain[J]. Exp Clin Endocrinol Diabetes, 2014, 122(2): 100-106.

[14] Jolivalt CG, Jiang Y, Freshwater JD, et al. Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats[J]. Diabetologia, 2006, 49(11): 2775-2785.

[15] Hernandez-Fonseca JP, Rincon J, Pedreanez A, et al. Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats. Exp Diabetes Res, 2009, 2009: 329632.

[16] Shafrir E. Diabetes in animals: Contribution to the understanding of diabetes by study of its etiopathology in animal models[J]. Diabetes mellitus, 2003, 231-255.

[17] ObrosovaIG, Ilnytska O, Lyzogubov VV, et al. High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductaseinhibition[J]. Diabetes, 2007, 56(10): 2598-1608.

[18] VincentAM, Hayes JM, McLean LL, et al. Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1[J]. Diabetes, 2009, 58(10): 2376-2385.

[19] Shafrir E, Ziv E, Mosthaf L. Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models[J]. Ann NY AcadSci, 1999, 892:223-246.

[20] Zhang F, Ye C, Li G, et al. The rat model of type 2 diabetic mellitus and its glycometabolismcharacters[J]. ExpAnim, 2003, 52:401-407.

[21] Islam MS, Choi H.Nongenetic model of type 2 diabetes: a comparative study[J]. Pharmacology, 2007, 79: 243-249.

[22] Dang JK, Wu Y, Cao H, et al. Establishment of a rat model of type II diabetic neuropathic pain[J]. Pain Med, 2014, 15(4): 637-646.

[23] 胡明财, 何建华, 章卓, 等.六昧地黄丸对2型糖尿病大鼠周围神经病变的影响[J]. Chinese Journal of New Drug, 2014, 23(3): 351-354.

[24] Hoke A. Animal models of peripheral neuropathies[J]. Neurotherapeutics, 2012, 9(2): 262-269.

[25] 殷娟, 张明红, 杨红英. 2型糖尿病大鼠周围神经病变模型的建立及相关指标检测[J]. 国际检验医学杂志, 2013, 01:1-2+5.

[26] 许锦秀, 马克涛, 李思源. P2X受体在CCI模型中介导疼痛的研究进展[J]. 现代生物医学进展, 2010, 14:2778-2780.

[27] Di VirgilioF.P2X Receptors and Inflammation[J]. Curr Med Chem, 2015, 22(7): 866-877.

[28] 赵聪, 余剑波. P2X3受体在神经病理性疼痛中的作用[J]. 中华临床医师杂志, 2011, 5:7056-7070.

[29] Burnstock G. Acupuncture: a novel hypothesis for the involvement of purinergicsignalling[J]. Med Hypotheses, 2009, 73(4): 470-472.

[30] Tu WZ, Cheng RD, Cheng B, et al. Analgesic effect of electroacupuncture on chronic neuropathic pain mediated by P2X3 receptors in rat dorsal root ganglion neurons[J]. NeurochemInt, 2012, 60(4): 379-386.

[31] Kobayashi K, Fukuoka T, Yamanaka H, et al. Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat[J]. J. Comp. Neurol, 2005, 481: 377-390.

[32] Aoki Y, Takahashi Y, Ohtori S, et al. Distribution and immunocytochemical characterization of dorsal root ganglion neurons innervating the lumbar intervertebral disc in rats: a review[J]. Life Sci, 2004, 74(21): 2627-2642.

[33] Xiao Z, Ou S, He WJ, et al. Role of midbrain periaqueductal gray P2X3 receptors in electroacupuncture-mediated endogenous pain modulatory systems[J].Brain Res, 2010, 1330:31-44.

[34] 赵浩, 余庆, 刘曾旭. P2X受体介导的神经病理痛的研究进展[J]. 南昌大学学报(医学版), 2013, 04:90-91+95.

[35] Mo G, Peleshok JC, Cao CQ, et al. Control of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons[J]. MolPharmacol, 2013, 83(3): 640-647.

[36] North RA, Verkhratsky A.Purinergic transmission in the central nervous system[J]. Pflugers Arch, 2006, 452:479-485.

[37] North RA. The P2X3 subunit: a molecular target in pain therapeutics[J]. CurrOpinInvestig Drugs, 2003, 4:833– 840.

[38] Fabbretti E, D'Arco M, Fabbro A, et al. Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide[J]. J Neurosci, 2006, 26(23): 6163-6171.

[39] 张琪, 谭颖颖. 低频电针刺激对慢性痛大鼠背根神经节P2X3受体表达的影响[J]. 陕西中医学院学报, 2011, 34:74-75.

[40] Wang S, Dai Y, Kobayashi K, et al. Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain[J]. Eur J Neurosci, 2012, 36(3): 2293-2301.

[41] Mo G, Grant R, O'Donnell D, et al. Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C[J]. Mol Pain, 2011, 7:14.

[42] Engelman HS, MacDermott AB. Presynaptic ionotropic receptors and control of transmitter release[J]. Nat Rev Neurosci, 2004, 5:135-145.

[43] Chen Y, Li GW, Wang C, et al. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state[J]. Pain, 2005, 119: 38–48.

[44] Wang C, Gu Y, Li GW, et al. A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats[J]. J Physiol, 2007, 584(Pt 1):191-203.

[45] 刘安东, 雷洁, 王元银, 等.三叉神经痛和P_2X受体的研究进展[J]. 国际口腔医学杂志, 2010, 02:174-177.

[46] Migita K, Moriyam T, Koguchi M, et al. Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy[J]. NeurosciLett, 2009, 452:200-203.

[47] 崔媛媛, 吴黄辉, 王兰, 等. 糖尿病机械性痛模型大鼠P2X3受体的时空表达[J]. 解剖学报, 2014, 04:540-544.

[48] Xing J, Lu J, Li J. Purinergic P2X receptors presynaptically increase glutamatergic synaptic transmission in dorsolateral periaqueductal gray[J]. Brain Res, 2008, 1208:46-55.

[49] Shi L, Zhang HH, Hu J, et al.Purinergic P2X receptors and diabetic neuropathic pain[J]. Sheng Li XueBao, 2012, 64(5): 531-542.

[50] Xu GY, Huang LY. Ca²⁺/calmodulin-dependent protein kinase ii potentiates ATP responses by promoting trafficking of P2X receptors[J]. ProcNatlAcadSci, 2004, 101(32): 11868-11873.

引用本文

魏骏骏,寿升芸,何晓芬,蒋永亮,方剑乔. P2X3受体在糖尿病神经痛动物模型中的研究进展[J].中国比较医学杂志,2015,25(5):62~66.

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最后修改日期:2015-04-03
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在线发布日期: 2015-05-29
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