十二五科技重大专项（2012ZX10004501-004-003，2012ZX10004501-004-004，2012ZX10004301-8）；国家自然科学基金（31370203）；科技部H7N9禽流感应急防控专项（KJYJ-2013-01-04）；协和青年教师培养项目（2012Y2，2012D15）。
CHEN Ting
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, ChinaBAO Lin-lin
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, ChinaZHU Hua
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, ChinaDENG Wei
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, ChinaXU Li-li
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, ChinaLV Qi
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, ChinaLI Feng-di
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, ChinaQIN Chuan
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Union Medicine College, Beijing 100021, China目的 建立新型禽源人流感病毒（H7N9）小鼠模型和可能的H7N9致病性和传播力研究。方法 H7N9病毒感染小鼠，并与同居小鼠合笼，研究同居小鼠的临床指征变化，病毒复制情况，病毒在组织中的分布，以及病理变化。通过观察同居小鼠的发病情况等方面研究H7N9病毒在同笼小鼠中的传播能力。结果 研究表明H7N9病毒能有效地感染小鼠并造成致死，可以通过直接接触传播感染小鼠并引起病理等改变。结论 建立了H7N9小鼠模型，并对小鼠通过接触传播感染进行了初步研究，为深入研究传播力奠定了基础。
Objective To research epidemic caused by a novel avian-origin human influenza (H7N9) virus in China underscores the need for studies on the pathogenicity and pandemic potential of the virus.Methods H7N9 virus infection in mice caged together with cohabitation mice to study changes in the clinical indications for cohabitation mice, viral replication of the virus in tissue distribution, and pathological changes. Results Our present study shows the H7N9 virus isolated from patients efficiently infects mice and causing lethal symptoms. In addition, the H7N9 virus could be transmitted to uninfected mice via direct contact and cause morbidity and pathological changes.Conclusion our mouse model of indirect infection can be used to study the pandemic potential of H7N9 virus in humans.
陈霆,鲍琳琳,朱华,邓巍,许黎黎,吕琦,李枫棣,秦川.新型禽源人流感病毒(H7N9)的小鼠感染模型和传播模型建立[J].中国比较医学杂志,2014,24(1):52~55.
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